| Full text | |
| Author(s): |
Fukumasu, Heidge
[1]
;
Silva, Tereza Cristina da
;
Avanzo, José Luis
;
Lima, Cyntia Esteves de
;
Mackowiak, Ivone Isabel
;
Atroch, André
;
Spinosa, Helenice de Souza
;
Moreno, Fernando Salvador
;
Dagli, Maria Lucia Zaidan
Total Authors: 9
|
| Affiliation: | [1] Universidade de São Paulo (USP). Faculdade de Medicina Veterinária e Zootecnia. Departamento de Patologia - Brasil
Total Affiliations: 9
|
| Document type: | Journal article |
| Source: | Cancer Letters; v. 233, n. 1, p. 158-164, Feb. 2006. |
| Field of knowledge: | Agronomical Sciences - Veterinary Medicine |
| Abstract | |
Guaraná (Paullinia cupana) is originally from Amazon, Brazil. Its effects on mouse hepatocarcinogenesis have been investigated in this study. Mice were treated with N-nitrosodiethylamine (DEN), received three different doses of P. cupana added to commercial food, and euthanized after 25 weeks. Gross lesions were quantified, and preneoplastic lesions (PNL) were histologically measured. Cellular proliferation was evaluated by immunobloting for the proliferating cell nuclear antigen (PCNA). The incidence and multiplicity of macroscopic lesions were reduced. The PNL number and PCNA expression were reduced in the highest P. cupana dose. According to these results, guaraná presented inhibitory effects on DEN hepatocarcinogenesis in mice. (AU) | |