Autor(es)

Borghi-Silva, Audrey ^[1] ; Di Thommazo, Luciana ^[1] ; Pantoni, Camila B. F. ^[1] ; Mendes, Renata G. ^[1] ; Salvini, Tania De Fatima ^[2] ; Costa, Dirceu ^[3]

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Carlos, Cardiopulm Physiotherapy Lab, Sao Paulo - Brazil

^[2] Univ Fed Sao Carlos, Unit Skeletal Muscle Plast, Phys Therapy Dept, Sao Paulo - Brazil

^[3] Univ Nine July, Phys Therapy Dept, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Respirology; v. 14, n. 4, p. 537-544, 2009.
• Citações Web of Science: 32

Resumo

Non-invasive ventilation (NIV) might improve peripheral muscle function and exercise capacity in severely disabled patients. This study evaluated the physiological impact of NIV on isokinetic concentric strength and endurance of lower limb muscles in patients with severe COPD. This clinical trial tested COPD patients (n = 24) and healthy subjects (n = 18). Subjects underwent isokinetic dynamometry tests while given either bi-level positive airway pressure ventilation (BV) or sham ventilation (SV), in a randomized order with 30 min of rest prior to each intervention. The inspiratory level of BV was set up to 14 cm H2O and expiratory pressure up to 6 cm H2O. Peripheral oxygen saturation (SpO(2)), heart rate (HR), systolic (SBP) and diastolic blood pressure (DBP) at the peak of exercise were measured for each intervention. Compared with controls, COPD patients had lower values of SpO(2) and HR (P < 0.01) during both BV and SV and lower values of DBP (P < 0.01) during BV. BV improved SpO(2) (P < 0.01), and reduced SBP in both COPD (P < 0.01) and control groups (P < 0.05) and reduced DBP in COPD patients (P < 0.01). BV also reduced the fatigue index in COPD patients when compared with SV (P = 0.003). Variation (BV-SV) of total work at the peak of the test was higher in the control group than in the COPD group (P < 0.05). BV improved SpO(2) and reduced the fatigability of the quadriceps muscle in patients with severe COPD. These results support the need for further evaluation of BV as adjunct during high-intensity strength exercise training in these patients. (AU)

• Processo FAPESP: 07/53202-9 - Efeitos de diferentes níveis de pressão positiva nas vias aéreas sobre o padrão ventilatório e a variabilidade da frequência cardíaca de pacientes submetidos à cirurgia de revascularização do miocárdio
• Beneficiário: Camila Bianca Falasco Pantoni
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 05/59427-7 - Efeito da modulação autonômica cardíaca em pacientes submetidos à cirurgia de revascularização do miocárdio e programa de fisioterapia: fase I da reabilitação cardiovascular
• Beneficiário: Audrey Borghi Silva
• Modalidade de apoio: Auxílio à Pesquisa - Regular