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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Light/dark cycle-dependent metabolic changes in adipose tissue of pinealectomized rats

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Autor(es):
Alonso-Vale, M. I. C. ; Borges-Silva, C. N. [2] ; Anhê, G. F. ; Andreotti, S. ; Machado, M. A. ; Cipolla-Neto, J. ; Lima, F. B.
Número total de Autores: 7
Tipo de documento: Artigo Científico
Fonte: Hormone and Metabolic Research; v. 36, n. 7, p. 474-479, July 2004.
Área do conhecimento: Ciências Biológicas - Fisiologia
Assunto(s):Metabolismo   Adipócitos   Glândula pineal   Resistência à insulina   Corticosterona
Resumo

We investigated the effects of pinealectomy on adipose tissue metabolism at different times of day. Adult male Wistar rats were divided into two groups: pinealectomized and control (sham-operated). Eight weeks after surgery, the animals were killed at three different times (at 8.00 a.m., at 4.00 p.m. and 11.00 p.m.). We collected blood samples for glucose, insulin, corticosterone, and leptin determinations, and periepididymal adipocytes for in vitro insulin-stimulated glucose uptake, oxidation, and incorporation into lipids. Pinealectomy caused insulin resistance as measured by 2-deoxyglucose uptake (a fall of ¡­ 40 % in the maximally insulin-stimulated rates) accompanied by hypercorticosteronemia at the three time points investigated without changes in plasma insulin an or leptin levels. Furthermore, pinealectomy increased the insulin-induced glucose incorporation into lipids (77 %) at 4.00 p.m. and insulin-induced glucose oxidation in the morning and in the afternoon, while higher rates were observed in the evening and in the morning in control rats. In conclusion, cell responsiveness to insulin was differentially affected by pineal ablation and time of day, and persistent insulin resistance was obtained in pinealectomized rats. We hypothesize that pinealectomy exposes the animal to an inadequate match between energy requirements and fuel mobilization. (AU)

Processo FAPESP: 99/04317-0 - O papel da glandula pineal na regulacao do metabolismo do tecido adiposo branco em ratos
Beneficiário:Fabio Bessa Lima
Modalidade de apoio: Auxílio à Pesquisa - Regular
Processo FAPESP: 98/15261-2 - O papel da glandula pineal na regulacao do metabolismo do tecido adiposo branco em ratos.
Beneficiário:Maria Isabel Cardoso Alonso-Vale
Modalidade de apoio: Bolsas no Brasil - Mestrado