The persistence of multifocal colonisation by a single ABC genotype of Candida albicans may predict the transition from commensalism to infection

Autor(es)

Chaves, Guilherme Maranhao ^[1] ; Santos, Fernanda Pahim ^[2] ; Colombo, Arnaldo Lopes ^[2]

Afiliação do(s) autor(es)

^[1] Univ Fed Rio Grande do Norte, Lab Micol Med & Mol, Dept Analises Clin & Toxicol, Fac Farm, BR-59072970 Natal, RN - Brazil

^[2] Univ Fed Sao Paulo, Lab Especial Micol, Disciplina Infectol, BR-04023062 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Memórias do Instituto Oswaldo Cruz; v. 107, n. 2, p. 198-204, MAR 2012.
• Citações Web of Science: 10

Resumo

Candida albicans is a common member of the human microbiota and may cause invasive disease in susceptible populations. Several risk factors have been proposed for candidaemia acquisition. Previous Candida multifocal colonisation among hospitalised patients may be crucial for the successful establishment of candidaemia. Nevertheless, it is still not clear whether the persistence or replacement of a single clone of C. albicans in multiple anatomical sites of the organism may represent an additional risk for candidaemia acquisition. Therefore, we prospectively evaluated the dynamics of the colonising strains of C. albicans for two groups of seven critically ill patients: group I included patients colonised by C. albicans in multiple sites who did not develop candidaemia and group II included patients who were colonised and who developed candidaemia. ABC and microsatellite genotyping of 51 strains of C. albicans revealed that patients who did not develop candidaemia were multiply colonised by at least two ABC genotypes of C. albicans, whereas candidaemic patients had highly related microsatellites and the same ABC genotype in colonising and bloodstream isolates that were probably present in different body sites before the onset of candidaemia. (AU)

• Processo FAPESP: 05/04442-1 - Caracterizações genotípicas e fenotípicas de diferentes isolados clínicos de Candida albicans quanto aos fatores de virulência
• Beneficiário: Guilherme Maranhão Chaves
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 07/05880-8 - Comparação genotípica e fenotípica de diferentes isolados clínicos de colonização e candidemia por Candida rugosa
• Beneficiário: Gisela Ramos Terçarioli
• Modalidade de apoio: Bolsas no Brasil - Mestrado