| Texto completo | |
| Autor(es): |
Minarini, Paulo R. R.
[1, 2, 3]
;
de Souza, Ana O.
[4]
;
Soares, Edson G.
[5]
;
Barata, Lauro E. S.
[6]
;
Silva, Celio L.
[2]
;
Bentley, Maria Vitoria L. B.
[3]
Número total de Autores: 6
|
| Afiliação do(s) autor(es): | [1] Univ Fed Sao Paulo, Inst Ciencias Ambientais Quim & Farmaceut, Diadema, SP - Brazil
[2] Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Bioquim & Imunol, Ribeirao Preto, SP - Brazil
[3] Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, BR-14049 Ribeirao Preto, SP - Brazil
[4] Inst Butantan, Lab Bioquim & Biofis, Sao Paulo - Brazil
[5] Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Patol, Ribeirao Preto, SP - Brazil
[6] Univ Estadual Campinas, Inst Quim, Campinas, SP - Brazil
Número total de Afiliações: 6
|
| Tipo de documento: | Artigo Científico |
| Fonte: | DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY; v. 38, n. 3, p. 259-263, MAR 2012. |
| Citações Web of Science: | 3 |
| Resumo | |
Conventional treatment of tuberculosis (TB) demands a long course therapy (6 months), known to originate multiple drug resistant strains (MDR-TB), which emphasizes the urgent need for new antituberculous drugs. The purpose of this study was to investigate a novel treatment for TB meant to improve patient compliance by reducing drug dosage frequency. Polymeric microparticles containing the synthetic analogue of neolignan, 1-phenyl-2-phenoxiethanone (LS-2), were obtained by a method of emulsification and solvent evaporation and chemically characterized. Only representative LS-2-loaded microparticles were considered for further studies involving experimental murine TB induced by Mycobacterium tuberculosis H37Rv ATCC 27294. The LS-2-loaded microparticles were spherical in shape, had a smooth wall and showed an encapsulation efficiency of 93% in addition to displaying sustained release. Chemotherapeutic potential of LS-2 entrapped in microparticles was comparable to control groups. These findings are encouraging and indicate that LS-2-loaded microparticles are a potential alternative to conventional chemotherapy of TB. (AU) | |
| Processo FAPESP: | 04/09465-7 - Laboratorio multiusuario de caracterizacao de sistemas de liberacao micro- e nanodispersos de farmacos. |
| Beneficiário: | Maria Vitória Lopes Badra Bentley |
| Modalidade de apoio: | Auxílio à Pesquisa - Programa Equipamentos Multiusuários |