| Texto completo | |
| Autor(es): |
de Oliveira, Jaqueline Carvalho
[1]
;
Scrideli, Carlos Alberto
[2]
;
Brassesco, Maria Sol
[2]
;
Morales, Andressa Gois
[1]
;
Pezuk, Julia Alejandra
[1]
;
Queiroz, Rosane de Paula
[2]
;
Yunes, Jose Andres
[3, 4]
;
Brandalise, Silvia Regina
[3, 4]
;
Tone, Luiz Gonzaga
[2, 1]
Número total de Autores: 9
|
| Afiliação do(s) autor(es): | [1] Univ Sao Paulo, Dept Genet, BR-14049900 Sao Paulo - Brazil
[2] Univ Sao Paulo, Dept Paediat, BR-14049900 Sao Paulo - Brazil
[3] Ctr Infantil Boldrini, Sao Paulo - Brazil
[4] Univ Campinas UNICAMP, Dept Paediat, Sao Paulo - Brazil
Número total de Afiliações: 4
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Leukemia Research; v. 36, n. 3, p. 293-298, MAR 2012. |
| Citações Web of Science: | 39 |
| Resumo | |
The present study aimed to analyze the expression profile of the microRNAs previously described as associated with childhood ALL, miR-92a, miR-100, miR-125a-5p, miR-128a, miR-181b, miR-196b and let-7e, and their association with biological/prognostic features in 128 consecutive samples of childhood acute lymphoblastic leukemia (ALL) by quantitative real-time PCR. A significant association was observed between higher expression levels of miR-196b and T-ALL, miR-100 and patients with low white blood cell count at diagnosis and t(12;21) positive ALL. These findings suggest a potential activity of these microRNAs in pediatric ALL biology. (C) 2011 Elsevier Ltd. All rights reserved. (AU) | |
| Processo FAPESP: | 09/10191-2 - Estudo da Influência de MicroRNAs na Leucemia Linfóide Aguda |
| Beneficiário: | Jaqueline Carvalho de Oliveira |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado |