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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Differential MiRNA expression in childhood acute lymphoblastic leukemia and association with clinical and biological features

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Autor(es):
de Oliveira, Jaqueline Carvalho [1] ; Scrideli, Carlos Alberto [2] ; Brassesco, Maria Sol [2] ; Morales, Andressa Gois [1] ; Pezuk, Julia Alejandra [1] ; Queiroz, Rosane de Paula [2] ; Yunes, Jose Andres [3, 4] ; Brandalise, Silvia Regina [3, 4] ; Tone, Luiz Gonzaga [2, 1]
Número total de Autores: 9
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Dept Genet, BR-14049900 Sao Paulo - Brazil
[2] Univ Sao Paulo, Dept Paediat, BR-14049900 Sao Paulo - Brazil
[3] Ctr Infantil Boldrini, Sao Paulo - Brazil
[4] Univ Campinas UNICAMP, Dept Paediat, Sao Paulo - Brazil
Número total de Afiliações: 4
Tipo de documento: Artigo Científico
Fonte: Leukemia Research; v. 36, n. 3, p. 293-298, MAR 2012.
Citações Web of Science: 39
Resumo

The present study aimed to analyze the expression profile of the microRNAs previously described as associated with childhood ALL, miR-92a, miR-100, miR-125a-5p, miR-128a, miR-181b, miR-196b and let-7e, and their association with biological/prognostic features in 128 consecutive samples of childhood acute lymphoblastic leukemia (ALL) by quantitative real-time PCR. A significant association was observed between higher expression levels of miR-196b and T-ALL, miR-100 and patients with low white blood cell count at diagnosis and t(12;21) positive ALL. These findings suggest a potential activity of these microRNAs in pediatric ALL biology. (C) 2011 Elsevier Ltd. All rights reserved. (AU)

Processo FAPESP: 09/10191-2 - Estudo da influência de microRNAs na leucemia linfóide aguda
Beneficiário:Jaqueline Carvalho de Oliveira
Linha de fomento: Bolsas no Brasil - Doutorado