Differential MiRNA expression in childhood acute lymphoblastic leukemia and association with clinical and biological features

Autor(es)

de Oliveira, Jaqueline Carvalho ^[1] ; Scrideli, Carlos Alberto ^[2] ; Brassesco, Maria Sol ^[2] ; Morales, Andressa Gois ^[1] ; Pezuk, Julia Alejandra ^[1] ; Queiroz, Rosane de Paula ^[2] ; Yunes, Jose Andres ^{[3, 4]} ; Brandalise, Silvia Regina ^{[3, 4]} ; Tone, Luiz Gonzaga ^{[2, 1]}

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Dept Genet, BR-14049900 Sao Paulo - Brazil

^[2] Univ Sao Paulo, Dept Paediat, BR-14049900 Sao Paulo - Brazil

^[3] Ctr Infantil Boldrini, Sao Paulo - Brazil

^[4] Univ Campinas UNICAMP, Dept Paediat, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Leukemia Research; v. 36, n. 3, p. 293-298, MAR 2012.
• Citações Web of Science: 39

Resumo

The present study aimed to analyze the expression profile of the microRNAs previously described as associated with childhood ALL, miR-92a, miR-100, miR-125a-5p, miR-128a, miR-181b, miR-196b and let-7e, and their association with biological/prognostic features in 128 consecutive samples of childhood acute lymphoblastic leukemia (ALL) by quantitative real-time PCR. A significant association was observed between higher expression levels of miR-196b and T-ALL, miR-100 and patients with low white blood cell count at diagnosis and t(12;21) positive ALL. These findings suggest a potential activity of these microRNAs in pediatric ALL biology. (C) 2011 Elsevier Ltd. All rights reserved. (AU)

• Processo FAPESP: 09/10191-2 - Estudo da influência de microRNAs na leucemia linfóide aguda
• Beneficiário: Jaqueline Carvalho de Oliveira
• Linha de fomento: Bolsas no Brasil - Doutorado