Brazilian urban population genetic structure reveals a high degree of admixture

Autor(es)

Giolo, Suely R. ^{[1, 2]} ; Soler, Julia M. P. ^[3] ; Greenway, Steven C. ^[4] ; Almeida, Marcio A. A. ^[1] ; de Andrade, Mariza ^[5] ; Seidman, J. G. ^[4] ; Seidman, Christine E. ^[4] ; Krieger, Jose E. ^[1] ; Pereira, Alexandre C. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Sch Med, Inst Heart, Lab Genet & Mol Cardiol, Sao Paulo - Brazil

^[2] Univ Fed Parana, Dept Stat, BR-81531990 Curitiba, Parana - Brazil

^[3] Univ Sao Paulo, Dept Stat, Sao Paulo - Brazil

^[4] Harvard Univ, Sch Med, Dept Genet, Boston, MA - USA

^[5] Mayo Clin, Dept Hlth Sci Res, Rochester, MN - USA

• Tipo de documento: Artigo Científico
• Fonte: European Journal of Human Genetics; v. 20, n. 1, p. 111-116, JAN 2012.
• Citações Web of Science: 57

Resumo

Advances in genotyping technologies have contributed to a better understanding of human population genetic structure and improved the analysis of association studies. To analyze patterns of human genetic variation in Brazil, we used SNP data from 1129 individuals - 138 from the urban population of Sao Paulo, Brazil, and 991 from 11 populations of the HapMap Project. Principal components analysis was performed on the SNPs common to these populations, to identify the composition and the number of SNPs needed to capture the genetic variation of them. Both admixture and local ancestry inference were performed in individuals of the Brazilian sample. Individuals from the Brazilian sample fell between Europeans, Mexicans, and Africans. Brazilians are suggested to have the highest internal genetic variation of sampled populations. Our results indicate, as expected, that the Brazilian sample analyzed descend from Amerindians, African, and/or European ancestors, but intermarriage between individuals of different ethnic origin had an important role in generating the broad genetic variation observed in the present-day population. The data support the notion that the Brazilian population, due to its high degree of admixture, can provide a valuable resource for strategies aiming at using admixture as a tool for mapping complex traits in humans. European Journal of Human Genetics (2012) 20, 111-116; doi:10.1038/ejhg.2011.144; published online 24 August 2011 (AU)

• Processo FAPESP: 07/58150-7 - Mapeamento genético de fatores de risco cardiovascular na população brasileira: uma abordagem de mapeamento baseada em núcleos familiares: Projeto Corações de Baependi
• Beneficiário: José Eduardo Krieger
• Modalidade de apoio: Auxílio à Pesquisa - Regular