Expression of cyclooxygenase-2 (COX-2) and p53 in neighboring invasive and in situ components of breast tumors

Autor(es)

Serra, Katia Piton ^[1] ; Sarian, Luis Otavio ^[1] ; Rodrigues-Peres, Raquel Mary ^[2] ; Vassallo, Jose ^{[3, 4, 5]} ; Soares, Fernando Augusto ^[3] ; Pinto, Glauce Aparecida ^[5] ; da Cunha, Isabela Werneck ^[3] ; Shinzato, Julia Yoriko ^[1] ; Derchain, Sophie F. M. ^[1]

Afiliação do(s) autor(es)

^[1] State Univ Campinas Unicamp, Dept Obstet & Gynecol, Fac Med Sci, BR-13083970 Campinas, SP - Brazil

^[2] Univ Estadual Campinas, Clin Pathol Lab, CAISM, Campinas, SP - Brazil

^[3] Hosp Canc A C Camargo, Fundacao Antonio Prudente Sao Paulo, Dept Pathol, Sao Paulo - Brazil

^[4] Univ Estadual Campinas, Dept Pathol, Lab Investigat & Mol Pathol, CIPED, Fac Med, Campinas, SP - Brazil

^[5] Univ Estadual Campinas, Lab Expt Pathol, CAISM, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: ACTA HISTOCHEMICA; v. 114, n. 3, p. 226-231, 2012.
• Citações Web of Science: 4

Resumo

The aim of the study was to assess the relationship between the expression of COX-2 and p53, hormone receptors and HER-2 in the in situ (DCIS) and invasive components of ductal carcinomas (IDC) of the same breast. The expression of COX-2, p53, and hormone receptors was assessed in 87 cases of IDC with contiguous areas of DCIS. Results showed that there was no difference in COX-2 expression comparing the in situ and invasive components of the tumors. In the in situ component, there was a statistically borderline increase in p53 expression in tumors that also expressed COX-2. ER-positive specimens were more common in the group of tumors that expressed COX-2 in the invasive component. From this study we conclude that the expression of COX-2 was similar in the in situ and invasive components of the breast carcinomas. COX-2 positivity was marginally related with the expression of p53 in the in situ components, and with the ER expression in the invasive components. (C) 2011 Elsevier GmbH. All rights reserved. (AU)

• Processo FAPESP: 08/08536-9 - Expressão da COX-2 em carcinomas de mama invasor e in situ e sua relação com a expressão de HER2, mutação p53 e receptores de estrógeno e de progesterona
• Beneficiário: Sophie Françoise Mauricette Derchain
• Modalidade de apoio: Auxílio à Pesquisa - Regular