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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Expression of cyclooxygenase-2 (COX-2) and p53 in neighboring invasive and in situ components of breast tumors

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Author(s):
Serra, Katia Piton [1] ; Sarian, Luis Otavio [1] ; Rodrigues-Peres, Raquel Mary [2] ; Vassallo, Jose [3, 4, 5] ; Soares, Fernando Augusto [3] ; Pinto, Glauce Aparecida [5] ; da Cunha, Isabela Werneck [3] ; Shinzato, Julia Yoriko [1] ; Derchain, Sophie F. M. [1]
Total Authors: 9
Affiliation:
[1] State Univ Campinas Unicamp, Dept Obstet & Gynecol, Fac Med Sci, BR-13083970 Campinas, SP - Brazil
[2] Univ Estadual Campinas, Clin Pathol Lab, CAISM, Campinas, SP - Brazil
[3] Hosp Canc A C Camargo, Fundacao Antonio Prudente Sao Paulo, Dept Pathol, Sao Paulo - Brazil
[4] Univ Estadual Campinas, Dept Pathol, Lab Investigat & Mol Pathol, CIPED, Fac Med, Campinas, SP - Brazil
[5] Univ Estadual Campinas, Lab Expt Pathol, CAISM, Sao Paulo - Brazil
Total Affiliations: 5
Document type: Journal article
Source: ACTA HISTOCHEMICA; v. 114, n. 3, p. 226-231, 2012.
Web of Science Citations: 4
Abstract

The aim of the study was to assess the relationship between the expression of COX-2 and p53, hormone receptors and HER-2 in the in situ (DCIS) and invasive components of ductal carcinomas (IDC) of the same breast. The expression of COX-2, p53, and hormone receptors was assessed in 87 cases of IDC with contiguous areas of DCIS. Results showed that there was no difference in COX-2 expression comparing the in situ and invasive components of the tumors. In the in situ component, there was a statistically borderline increase in p53 expression in tumors that also expressed COX-2. ER-positive specimens were more common in the group of tumors that expressed COX-2 in the invasive component. From this study we conclude that the expression of COX-2 was similar in the in situ and invasive components of the breast carcinomas. COX-2 positivity was marginally related with the expression of p53 in the in situ components, and with the ER expression in the invasive components. (C) 2011 Elsevier GmbH. All rights reserved. (AU)

FAPESP's process: 08/08536-9 - Expression of COX-2 in invasive and in situ breast carcinoma and its relation to HER2 expression, p53 mutation and estrogen and progesterone receptors
Grantee:Sophie Françoise Mauricette Derchain
Support Opportunities: Regular Research Grants