Immunolocalization of bone morphogenetic protein 2 during the early healing events after guided bone regeneration

Autor(es)

De Marco, Andrea Carvalho ^[1] ; Neves Jardini, Maria Aparecida ^[2] ; Modolo, Filipe ^[3] ; Nunes, Fabio Daumas ^[1] ; Alves de Lima, Luiz Antonio Pugliesi ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Dept Stomatol, Sao Paulo - Brazil

^[2] Univ Estadual, UNESP, Fac Odontol, Dept Diag & Surg, Paulista - Brazil

^[3] Univ Fed Santa Catarina, Dept Pathol, Florianopolis, SC - Brazil

• Tipo de documento: Artigo Científico
• Fonte: ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY; v. 113, n. 4, p. 533-541, APR 2012.
• Citações Web of Science: 5

Resumo

Objective. The objective of this study was to evaluate the immunolocalization of bone morphogenetic protein 2 (BMP-2) after autogenous block grafting covered or not with an e-PTFE membrane. Study Design. Forty-eight rats were divided into 2 groups, autogenous block graft (B) and autogenous block graft + e-PTFE membrane (MB), and were evaluated by immunohistochemistry at baseline and 3, 7, 14, 21, and 45 days. Results. The largest number of positive cells in the recipient bed was observed after 3 days in both groups. At the graft border, the largest number of positive cells was seen after 7 days in group B and after 14 days in group MB. The highest proportion of staining in the graft was observed after 3 days in group B and after 21 days in group MB. Conclusions. High proportions of stain were related to intense revascularization and osteogenesis. Except for the interface, BMP-2 staining occurred later in group MB than in group B in all structures analyzed. (Oral Surg Oral Med Oral Pathol Oral Radiol 2012;113:533-541) (AU)

• Processo FAPESP: 00/11085-7 - Revascularização de enxerto ósseo autógeno em bloco associado ou não a membrana de PTFE-e
• Beneficiário: Luiz Antonio Pugliesi Alves de Lima
• Modalidade de apoio: Auxílio à Pesquisa - Regular