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(Referência obtida automaticamente do Google Scholar, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Anatomy, function and regulation of neuropeptide EI (NEI)

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Autor(es):
Bittencourt, Jackson [1, 2] ; Celis, Maria Ester [3]
Número total de Autores: 2
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Inst Psychol, Ctr Neurosci & Behav, Sao Paulo - Brazil
[2] Univ Sao Paulo, Inst Biomed Sci, Dept Anat, Lab Chem Neuroanat, Sao Paulo - Brazil
[3] Univ Nacl Cordoba, Fac Ciencias Med, Catedra Bacteriol & Virol Med, Lab Ciencias Fisiol, RA-5000 Cordoba - Argentina
Número total de Afiliações: 3
Tipo de documento: Artigo Científico
Fonte: Peptides; v. 29, n. 8, p. 1441-1450, Aug. 2008.
Área do conhecimento: Ciências Biológicas - Morfologia
Citações Web of Science: 18
Assunto(s):Neuropeptídeos   Isoleucina   Hormônios   Neurotransmissores
Resumo

This review is focused on the anatomy, role and behavior of neuropeptide-glutamic acid-isoleucine (NEI), providing a general report on the neuropeptide. In addition to hormone release, this peptide also takes part in the regulation of grooming behavior and locomotor activity. NEI is produced by cleavage of prepro-MCH that probably takes place at the Lys129-Arg130 and Arg145-Arg146 sites (the glycine residue on the C-terminus of NEI strongly suggests that this peptide is amidated). This same prohormone is also the precursor of MCH, widely studied in relation to food and water intake, and NGE, of which little is known. NEI and MCH are extensively colocalized throughout the central nervous system (CNS), and NEI is also present in peripheral tissues. The latter is also effective in stimulating luteinizing hormone (LH) release and, to a lesser extent, FSH from primary pituitary cell cultures. In addition to releasing LH from the medial eminence, NEI also acts directly on gonadotropes. Lastly, this neuropeptide also acts at the CNS level on gonadotropin-releasing hormone (GnRH) neurons. (AU)

Processo FAPESP: 04/13849-5 - Circuitos peptidérgicos envolvidos na organização do comportamento alimentar
Beneficiário:Jackson Cioni Bittencourt
Modalidade de apoio: Auxílio à Pesquisa - Temático