Candida colonisation as a source for candidaemia

Autor(es)

Miranda, L. N. ^{[1, 2, 3]} ; van der Heijden, I. M. ^{[1, 2]} ; Costa, S. F. ^{[1, 2, 4]} ; Sousa, A. P. I. ^{[1, 2]} ; Sienra, R. A. ^{[1, 2]} ; Gobara, S. ^[4] ; Santos, C. R. ^[4] ; Lobo, R. D. ^[4] ; Pessoa, Jr., V. P. ^[5] ; Levin, A. S. ^{[1, 2, 4]}

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Dept Infect Dis, Sao Paulo - Brazil

^[2] Univ Sao Paulo, LIM 54, Sao Paulo - Brazil

^[3] Hosp Geral Itapecer Serra SECONCI, Sao Paulo - Brazil

^[4] Univ Sao Paulo, Hosp Clin, Dept Infect Control, BR-05508 Sao Paulo - Brazil

^[5] Inst Infectol Emilio Ribas, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Journal of Hospital Infection; v. 72, n. 1, p. 9-16, MAY 2009.
• Citações Web of Science: 115

Resumo

Candida spp. are important healthcare-associated pathogens. Identifying the source of infection is important for prevention and control strategies. The objective of this study was to evaluate candida colonisation sites as potential sources for candidaemia. Sixty-three consecutive patients with a positive blood culture for candida were included. Surveillance cultures were collected from urine, rectum, oropharynx, skin, intravascular catheter tip and skin around catheter. Molecular typing was performed when the same species of candida was isolated from blood and surveillance sites of a patient. C. albicans was associated with 42% of candidaemias, C. parapsilosis 33%, C. tropicalis 16% and C. guilliermondii, C. krusei, C. glabrata, C. holmii and C. metapsilosis were all 2% each. Six of 10 C. parapsilosis catheter tip isolates were indistinguishable from corresponding blood isolates (all in neonates). C. albicans isolates from blood were indistinguishable from corresponding gastrointestinal, tract isolates in 13 of 26 patients and from catheter tip isolates in two patients. In conclusion, the results suggest that gastrointestinal colonisation is the probable source of C. albicans candidaemia and C. parapsilosis is exogenous. (C) 2009 The Hospital, Infection Society. Published by Elsevier Ltd. All rights reserved. (AU)

• Processo FAPESP: 03/10008-7 - Colonização por Candida em indivíduos com candidemia
• Beneficiário: Anna Sara Shafferman Levin
• Modalidade de apoio: Auxílio à Pesquisa - Regular