Modulatory effects of rutin on biochemical and hematological parameters in hypercholesterolemic Golden Syrian hamsters

Autor(es)

Kanashiro, Alexandre ^[1] ; Andrade, Daiani C. O. ^[2] ; Kabeya, Luciana M. ^[1] ; Turato, Walter M. ^[2] ; Faccioli, Lucia H. ; Uyemura, Sergio A. ^[3] ; Lucisano-Valim, Yara M. ^{[3, 1]}

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Dept Quim & Fis, Fac Ciencias Farmaceut Ribeirao Preto, BR-14040903 Ribeirao Preto, SP - Brazil

^[2] Univ Sao Paulo, Dept Imunol Basica & Aplicada, Fac Med Ribeirao Preto, BR-14049900 Ribeirao Preto, SP - Brazil

^[3] Univ Sao Paulo, Dept Anal Clin Toxicol & Bromatol, Fac Ciencias Farmaceut Ribeirao Preto, BR-14040903 Ribeirao Preto, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Anais da Academia Brasileira de Ciências; v. 81, n. 1, p. 67-72, MAR 2009.
• Citações Web of Science: 12

Resumo

Flavonoids have been reported to exhibit several pharmacological properties, mainly in cardiovascular and inflammatory diseases. In the present study, we observed that rutin, a known glycosylated flavonoid isolated from Dimorphandra mollis, had a lowering effect on plasma triglyceride levels of diet-induced hypercholesterolemic Golden Syrian hamsters, but did not change total cholesterol and high-density lipoprotein cholesterol levels. Moreover, high-fat or rutin supplemented diets showed no immunotoxic effects, since no significant changes were observed on total white blood cells, granulocytes and mononuclear cells, as well as on the neutrophil apoptosis degree, when compared to untreated animals. Therefore, rutin seems to be a selective and non-toxic modulator of hypercholesterolemia, which can be promising for the development of new drugs. (AU)

• Processo FAPESP: 01/14086-7 - Estudo da participação dos neutrófilos no desenvolvimento e instalação da aterosclerose: efeito modulatório da catequina nas funções destas células
• Beneficiário: Alexandre Kanashiro
• Modalidade de apoio: Bolsas no Brasil - Doutorado