| Texto completo | |
| Autor(es): |
de Lima Junior, Mario Maciel
[1]
;
Reis, Leonardo Oliveira
[1, 2]
;
Trindade Guilhen, Ana Carolina
[1]
;
Granja, Fabiana
[1]
;
de Lima Oliveira, Mariana Nicolau
[1]
;
Ferreira, Ubirajara
[2]
;
Cunha, Lucas Leite
[1]
;
Ward, Laura Sterian
[1]
Número total de Autores: 8
|
| Afiliação do(s) autor(es): | [1] Univ Campinas FCM Unicamp, Fac Med Sci, Lab Canc Mol Genet, Sao Paulo - Brazil
[2] Univ Campinas FCM Unicamp, Fac Med Sci, Div Urol Oncol, Campinas, SP - Brazil
Número total de Afiliações: 2
|
| Tipo de documento: | Artigo Científico |
| Fonte: | MEDICAL ONCOLOGY; v. 29, n. 4, p. 2889-2894, DEC 2012. |
| Citações Web of Science: | 9 |
| Resumo | |
We investigated the role of N-acetyltransferases (NAT) in prostate cancer (PCa) susceptibility. NAT are polymorphic in the population and metabolize important carcinogenic products directly involved in the tumor initiation process. This prospective case-control study utilized the polymerase chain reaction-based restriction fragment length polymorphism method and comprised a cohort of consecutive 478 individuals: 126 men with prostate cancer; 101 men with benign prostatic hyperplasia (BPH); and a control health population of 177 female and 74 male blood donors from the same region. NAT2 slow or fast acetylators genotypes were determined by the combination of four variant alleles. Lifetime occupational history, dietary patterns, cigarette smoking and other anamnestic data were obtained by interviews. We were not able to find any correlation among smoking, dietary patterns, parameters of tumor aggressiveness or patient outcome and any NAT2 genotypes or phenotypes considered in separate or in different combinations. However, there was an association between NAT2T481C (OR = 0.47; 95% CI = 0.26-0.84; P = 0.01) and NAT2A803G (OR = 0.57; 95% CI = 0.33-0.97; P = 0.04) polymorphisms and PCa protection. Conversely, the presence of NAT2G857A genotype increased the risk of PCa more than 3 times (OR = 3.57; 95% CI = 1.39-9.15; P = 0.005). Slow acetylator NAT2{*}7A and NAT2{*}6B genotypes occurred in 10.31% of PCa but in none of BPH patients (P = 0.0007). The control health population confirmed the results and allowed the exclusion of possible biases caused by gender influence on genotype inheritance and by the inclusion of not diagnosed prostate diseases patients among the control individuals. We suggest that the investigation of germline polymorphisms of NAT2 gene may be useful in the assessment of Latin American patients at risk of BPH and PCa. (AU) | |
| Processo FAPESP: | 03/02309-7 - Avaliação de marcadores moleculares no diagnóstico, seguimento e prognóstico de pacientes com câncer da tiróide |
| Beneficiário: | Laura Sterian |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 04/02058-7 - Influência do perfil genotípico de NAT2 na susceptibilidade ao câncer e na resposta terapêutica de pacientes oncológicos |
| Beneficiário: | Ana Carolina Trindade Guilhen |
| Modalidade de apoio: | Bolsas no Brasil - Programa Capacitação - Treinamento Técnico |
| Processo FAPESP: | 03/11026-9 - Influencia do perfil genotipico de nat2 na susceptibilidade ao cancer e na resposta terapeutica de pacientes oncologicos. |
| Beneficiário: | Laura Sterian |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |