Busca avançada
Ano de início
Entree
(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Brazilian psychiatric brain bank: a new contribution tool to network studies

Texto completo
Autor(es):
Mostrar menos -
de Oliveira, K. C. [1, 2, 3, 4] ; Nery, F. G. [4] ; Ferreti, R. E. L. [1, 2] ; Lima, M. C. [2, 5] ; Cappi, C. [3] ; Machado-Lima, A. [3, 6] ; Polichiso, L. [2, 5] ; Carreira, L. L. [2, 4] ; Avila, C. [2, 4] ; Alho, A. T. D. L. [2, 7] ; Brentani, H. P. [8, 3] ; Miguel, E. C. [3] ; Heinsen, H. [7] ; Jacob-Filho, W. [2, 1] ; Pasqualucci, C. A. [1, 2] ; Lafer, B. [4] ; Grinberg, L. T. [9, 2]
Número total de Autores: 17
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Sch Med, Dept Pathol, Sao Paulo - Brazil
[2] Univ Sao Paulo, Sch Med, Brazilian Aging Brain Study Grp BBBABSG LIM 22, Sao Paulo - Brazil
[3] Univ Sao Paulo, Sch Med, Dept Psychiat, Obsess Compuls Res Grp PROTOC, Sao Paulo - Brazil
[4] Univ Sao Paulo, Sch Med, Dept Psychiat, Bipolar Disorder Res Grp PROMAN, Sao Paulo - Brazil
[5] Albert Einstein Res & Educ Inst, Sao Paulo - Brazil
[6] Univ Sao Paulo EACH USP, Sch Arts Sci & Humanities, Sao Paulo - Brazil
[7] Wuerzburg Univ, Morphol Brain Res Unit, Wurzburg - Germany
[8] Hosp Canc AC Camargo, Sao Paulo - Brazil
[9] UCSF, Dept Neurol, Memory & Aging Ctr, San Francisco, CA 94143 - USA
Número total de Afiliações: 9
Tipo de documento: Artigo Científico
Fonte: CELL AND TISSUE BANKING; v. 13, n. 2, p. 315-326, JUN 2012.
Citações Web of Science: 4
Resumo

There is an urgent need for expanding the number of brain banks serving psychiatric research. We describe here the Psychiatric Disorders arm of the Brain Bank of the Brazilian Aging Brain Study Group (Psy-BBBABSG), which is focused in bipolar disorder (BD) and obsessive compulsive disorder (OCD). Our protocol was designed to minimize limitations faced by previous initiatives, and to enable design-based neurostereological analyses. The Psy-BBBABSG first milestone is the collection of 10 brains each of BD and OCD patients, and matched controls. The brains are sourced from a population-based autopsy service. The clinical and psychiatric assessments were done by an expert team including psychiatrists, through an informant. One hemisphere was perfused-fixed to render an optimal fixation for conducting neurostereological studies. The other hemisphere was comprehensively dissected and frozen for molecular studies. In 20 months, we collected 36 brains. A final report was completed for 14 cases: 3 BDs, 4 major depressive disorders, 1 substance use disorder, 1 mood disorder NOS, 3 obsessive compulsive spectrum symptoms, 1 OCD and 1 schizophrenia. The majority were male (64%), and the average age at death was 67.2 +/- 9.0 years. The average postmortem interval was 16 h. Three matched controls were collected. The pilot stage confirmed that the protocols are well fitted to reach our goals. Our unique autopsy source makes possible to collect a fairly number of high quality cases in a short time. Such a collection offers an additional to the international research community to advance the understanding on neuropsychiatric diseases. (AU)

Processo FAPESP: 09/51482-0 - Analise estereologica postmortem das principais regioes cerebrais de individuos portadores de transtorno afetivo bipolar
Beneficiário:Beny Lafer
Linha de fomento: Auxílio à Pesquisa - Regular