Pro-inflammatory cytokines predominate in the brains of dogs with visceral leishmaniasis: A natural model of neuroinflammation during systemic parasitic infection

Autor(es)

Melo, Guilherme D. ; Seraguci, Tulio F. ; Schweigert, Augusto ; Silva, Jose Eduardo S. ; Grano, Fernanda G. ; Peiro, Juliana R. ^[1] ; Lima, Valeria M. F. ^[1] ; Machado, Gisele F. ^[1]

Afiliação do(s) autor(es)

^[1] UNESP Univ Estadual Paulista, Coll Vet Med, Dept Anim Clin Surg & Reprod, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Veterinary Parasitology; v. 192, n. 1-3, p. 57-66, FEB 18 2013.
• Citações Web of Science: 14

Resumo

Visceral leishmaniasis is a multisystemic zoonotic disease that can manifest with several symptoms, including neurological disorders. To investigate the pathogenesis of brain alterations occurring during visceral leishmaniasis infection, the expression of the cytokines IL-1 beta, IL-6, IL-10, IL-12p40, IFN-gamma, TGF-beta and TNF-alpha and their correlations with peripheral parasite load were evaluated in the brains of dogs naturally infected with Leishmania infantum. IL-1 beta, IFN-gamma and TNF-alpha were noticeably up-regulated, and IL-10, TGF-beta and IL-12p40 were down-regulated in the brains of infected dogs. Expression levels did not correlate with parasite load suggestive that the brain alterations are due to the host's immune response regardless of the phase of the disease. These data indicate the presence of a proinflammatory status in the nervous milieu of dogs with visceral leishmaniasis especially because IL-1 beta and TNF-alpha are considered key factors for the initiation, maintenance and persistence of inflammation. (c) 2012 Elsevier B.V. All rights reserved. (AU)

• Processo FAPESP: 09/53309-3 - Lesões no encéfalo de cães com leishmaniose: estudo da expressão gênica de mediadores pró e antiinflamatórios e da provável influência dos inibidores de metaloproteinases TIMPs (1 e 2) na migração de linfócitos T e B
• Beneficiário: Gisele Fabrino Machado
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 10/12473-2 - Avaliação da expressão gênica de citocinas no encéfalo de cães com leishmaniose visceral
• Beneficiário: Guilherme Dias de Melo
• Modalidade de apoio: Bolsas no Brasil - Mestrado