An intravenous implantable glucose/dioxygen biofuel cell with modified flexible carbon fiber electrodes

Autor(es)

Sales, Fernanda C. P. F. ^[1] ; Iost, Rodrigo M. ^[2] ; Martins, Marccus V. A. ^[1] ; Almeida, Maria C. ^[1] ; Crespilho, Frank N. ^[2]

Afiliação do(s) autor(es)

^[1] Univ Fed ABC, Ctr Ciencias Nat & Humanas, BR-09210970 Santo Ndre, SP - Brazil

^[2] Univ Sao Paulo, IQSC, BR-13560970 Sao Carlos, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: LAB ON A CHIP; v. 13, n. 3, p. 468-474, 2013.
• Citações Web of Science: 63

Resumo

An intravenous implantable glucose/dioxygen hybrid enzyme-Pt micro-biofuel cell (BFC) was investigated. In this miniaturized BFC, a flexible carbon fiber (FCF) microelectrode modified with neutral red redox mediator and glucose oxidase was used as the bioanode, and an FCF modified with platinum nanoparticles stabilized on PAMAM-G4 dendrimer was used as the cathode. In vitro experiments conducted using the BFC in a phosphate buffer solution (50 mmol L-1, pH = 7.2) and glucose (47 mmol L-1) showed high electrocatalytic performance with an open circuit voltage (OCV) of 400 mV, a maximum current density of 2700 mu A cm(-2) at 0.0 V and a maximum output power of 200 mu W cm(-2) at 250 mV. Under physiological conditions, glucose from rat blood is used as a fuel in anodic reactions and dissolved molecular oxygen is used as the oxidizing agent on the cathode. For in vivo experiments, the BFC was inserted into the jugular vein of a living rat (Rattus novergicus) using a catheter (internal diameter 0.5 mm). The power density of the implantable BFC was evaluated over a period of 24 h, and an OCV of 125 mV with a maximum power density of 95 mu W cm(-2) was obtained at 80 mV. (AU)

• Processo FAPESP: 09/15558-1 - Interação entre biomoléculas e sistemas celulares com nanoestruturas 0D, 1D e 2D utilizando métodos eletroquímicos
• Beneficiário: Frank Nelson Crespilho
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 11/01541-0 - Desenvolvimento de bioanodos constituídos por glicose oxidase e frutose desidrogenase e suas formas recombinantes para aplicação em protótipos de biocélulas a combustível enzimáticas: geração de energia a partir da biomassa (cana-de-açúcar)
• Beneficiário: Frank Nelson Crespilho
• Modalidade de apoio: Auxílio à Pesquisa - Regular