Advanced search
Start date
Betweenand
Related content
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

An intravenous implantable glucose/dioxygen biofuel cell with modified flexible carbon fiber electrodes

Full text
Author(s):
Sales, Fernanda C. P. F. [1] ; Iost, Rodrigo M. [2] ; Martins, Marccus V. A. [1] ; Almeida, Maria C. [1] ; Crespilho, Frank N. [2]
Total Authors: 5
Affiliation:
[1] Univ Fed ABC, Ctr Ciencias Nat & Humanas, BR-09210970 Santo Ndre, SP - Brazil
[2] Univ Sao Paulo, IQSC, BR-13560970 Sao Carlos, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: LAB ON A CHIP; v. 13, n. 3, p. 468-474, 2013.
Web of Science Citations: 63
Abstract

An intravenous implantable glucose/dioxygen hybrid enzyme-Pt micro-biofuel cell (BFC) was investigated. In this miniaturized BFC, a flexible carbon fiber (FCF) microelectrode modified with neutral red redox mediator and glucose oxidase was used as the bioanode, and an FCF modified with platinum nanoparticles stabilized on PAMAM-G4 dendrimer was used as the cathode. In vitro experiments conducted using the BFC in a phosphate buffer solution (50 mmol L-1, pH = 7.2) and glucose (47 mmol L-1) showed high electrocatalytic performance with an open circuit voltage (OCV) of 400 mV, a maximum current density of 2700 mu A cm(-2) at 0.0 V and a maximum output power of 200 mu W cm(-2) at 250 mV. Under physiological conditions, glucose from rat blood is used as a fuel in anodic reactions and dissolved molecular oxygen is used as the oxidizing agent on the cathode. For in vivo experiments, the BFC was inserted into the jugular vein of a living rat (Rattus novergicus) using a catheter (internal diameter 0.5 mm). The power density of the implantable BFC was evaluated over a period of 24 h, and an OCV of 125 mV with a maximum power density of 95 mu W cm(-2) was obtained at 80 mV. (AU)

FAPESP's process: 09/15558-1 - Biomolecules and cellular system interaction with nanostructures 0D, 1D and 2D by using electrochemical methods
Grantee:Frank Nelson Crespilho
Support Opportunities: Regular Research Grants
FAPESP's process: 11/01541-0 - Development of bioanodes composed by glucose oxidase and fructose dehydrogenase and its recombinant structures for aplication in prototype of biofuel cell: power generation from biomass (sugar cane)
Grantee:Frank Nelson Crespilho
Support Opportunities: Regular Research Grants