Lack of evidence to support the association of a single IL28B genotype SNP rs12979860 with the HTLV-1 clinical outcomes and proviral load

Autor(es)

Sanabani, Sabri Saeed ^{[1, 2]} ; Nukui, Youko ^[3] ; Pereira, Juliana ^[3] ; da Costa, Antonio Charlys ^[1] ; Soares de Oliveira, Ana Carolina ^[1] ; Pessoa, Rodrigo ^[1] ; Leal, Fabio Eudes ^[4] ; Segurado, Aluisio C. ^[5] ; Kallas, Esper Georges ^[4] ; Sabino, Ester Cerdeira ^[5]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Clin Lab, Dept Pathol, LIM 03, HC, Sch Med, Sao Paulo - Brazil

^[2] Sao Paulo Inst Trop Med, Sao Paulo - Brazil

^[3] Univ Sao Paulo, Dept Hematol, Sao Paulo - Brazil

^[4] Univ Sao Paulo, Div Clin Immunol & Allergy, Sch Med, Sao Paulo - Brazil

^[5] Univ Sao Paulo, Dept Infect Dis, Sch Med, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: BMC INFECTIOUS DISEASES; v. 12, DEC 23 2012.
• Citações Web of Science: 9

Resumo

Background: The Interleukin 28B (IL28B) rs12979860 polymorphisms was recently reported to be associated with the human T-cell leukemia virus type 1 (HTLV-1) proviral load (PvL) and the development of the HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Methods: In an attempt to examine this hypothesis, we assessed the association of the rs12979860 genotypes with HTLV-1 PvL levels and clinical status in 112 unrelated Brazilian subjects (81 HTLV-1 asymptomatic carriers, 24 individuals with HAM/TSP and 7 with Adult T cell Leukemia/Lymphoma (ATLL)). Results: All 112 samples were successfully genotyped and their PvLs compared. Neither the homozygote TT nor the heterozygote CT mutations nor the combination genotypes (TT/CT) were associated with a greater PvL. We also observed no significant difference in allele distribution between asymptomatic carriers and patients with HTLV-1 associated HAM/TSP. Conclusions: Our study failed to support the previously reported positive association between the IL28B rs12979860 polymorphisms and an increased risk of developing HAM/TSP in the Brazilian population. (AU)

• Processo FAPESP: 10/08550-1 - Expansão clonal de células T e níveis de carga proviral entre portadores assintomáticos de HTLV-1
• Beneficiário: Ester Cerdeira Sabino
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 11/12297-2 - Análise dos transcritos de miRNAs, REX e tax em células T no curso da infecção pelo HTLV-1, utilizando sequenciamento de nova geração
• Beneficiário: Sabri Saeed Mohammed Ahmed Al-Sanabani
• Modalidade de apoio: Auxílio à Pesquisa - Regular