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(Referência obtida automaticamente do SciELO, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Lack of tax diversity for tropical spastic paraparesis/human T-cell lymphotropic virus type 1 (HTLV-I) associated myelopathy development in HTLV-I-infected subjects in São Paulo, Brazil

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Autor(es):
J Casseb ; LMI Fukumori [2] ; MPP Vergara [3] ; S Sanabani [4] ; PE Marchiori [5] ; AJS Duarte [6] ; ACP de Oliveira [7]
Número total de Autores: 7
Tipo de documento: Artigo Científico
Fonte: Memórias do Instituto Oswaldo Cruz; v. 101, n. 3, p. 273-276, 2006-05-00.
Resumo

The product of human T-cell lymphotropic virus type 1 (HTLV-1) tax gene has a transactivating effect of the viral and cellular gene expression. Genetic variations in this gene have been correlated with differences in clinical outcomes. Based upon its diversity, two closely related substrains, namely tax A and tax B, have been described. The tax A substrain has been found at a higher frequency among human T-cell leukemia virus type 1 (TSP/HAM) patients than among healthy HTLV-I-infected asymptomatic subjects in Japan. In this study, we determined the distribution of tax substrains in HTLV-I-infected subjects in the city of São Paulo, Brazil. Using the ACCII restriction enzyme site, we detected only tax A substrain from 48 TSP/HAM patients and 28 healthy HTLV-I carriers. The sequenced tax genes from nine TSP/HAM patients and five asymptomatic HTLV-I carriers showed a similar pattern of mutation, which characterizes tax A. Our results indicate that HTLV-I tax subtypes have no significant influences on TSP/HAM disease progression. Furthermore, monophyletic introduction of HTLV-I to Brazil probably occurred during the African slave trade many years ago. (AU)

Processo FAPESP: 99/11188-1 - Perfil de citocinas e quantificação de carga viral de DNA de HTLV-I em indivíduos infectados pelo HIV e co-infectados pelo vírus HTLV-I
Beneficiário:Jorge Simao do Rosario Casseb
Modalidade de apoio: Auxílio à Pesquisa - Regular
Processo FAPESP: 00/12761-6 - Perfil de citocinas e quantificação de carga viral de DNA de HTLV-1 em indivíduos infectados por retrovírus
Beneficiário:Patricia Aparecida Montanheiro
Modalidade de apoio: Bolsas no Brasil - Mestrado