Toward pH-controllable bioelectrocatalysis for hydrogen peroxide based on polymer brushes

Autor(es)

Antonio, Tamara R. T. A. ^[1] ; Cabral, Murilo F. ^[2] ; Cesarino, Ivana ^[3] ; Machado, Sergio A. S. ^[3] ; Pedrosa, Valber A. ^[1]

Afiliação do(s) autor(es)

^[1] UNESP, Inst Biosci, Dept Chem & Biochem, Botucatu, SP - Brazil

^[2] Univ Estadual Campinas, Inst Biol, Dept Genet Evolut & Bioagents, Campinas, SP - Brazil

^[3] Univ Sao Paulo, Inst Quim Sao Carlos, Sao Carlos, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Electrochemistry Communications; v. 29, p. 41-44, APR 2013.
• Citações Web of Science: 18

Resumo

In the present work, a biosensor was built with smart material based on polymer brushes. The biosensor demonstrated a pH-sensitive on-off property, and it was further used to control or modulate the electrochemical responses of the biosensor. This property could be used to realize pH-controlled electrochemical reaction of hydrogen peroxide and HRP immobilized on polymer brushes. The composite film also showed excellent amperometric i-t response toward hydrogen peroxide in the concentration range of 0-13 mu M. In future, this platform might be used for self-regulating targeted diagnostic, drug delivery and biofuel cell based on controllable bioelectrocatalysis. (c) 2013 Elsevier B.V. All rights reserved. (AU)

• Processo FAPESP: 10/07478-5 - Amplificação da respostas biocatalíticas em nanoestruturas de ouro utilizando ressonância plasmônica de superfície localizada
• Beneficiário: Valber de Albuquerque Pedrosa
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores