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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Angiogenic switch during tumor progression of carcinoma ex-pleomorphic adenoma

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Autor(es):
Soares, A. B. ; Juliano, P. B. ; Araujo, V. C. [3] ; Metze, K. ; Altemani, A.
Número total de Autores: 5
Tipo de documento: Artigo Científico
Fonte: Virchows Archiv; v. 451, n. 1, p. 65-71, July 2007.
Área do conhecimento: Ciências da Saúde - Medicina
Assunto(s):Anatomia patológica   Neovascularização patológica   Invasividade neoplásica   Carcinoma   Adenoma pleomórfico
Resumo

We analyzed the tumor vascularization in carcinomas ex-pleomorphic adenoma (CXPA) to investigate the angiogenic switch during the malignant transformation of pleomorphic adenoma (PA) to carcinoma and during tumor progression. In eight cases of early CXPA (intracapsular and minimally invasive tumors), eight of advanced CXPA (widely invasive tumors), and ten of PA without malignant transformation, tumor vascularization was assessed in histological samples by measuring total microvascular area (TVA) and microvessel density (MVD) using CD34 and CD105 antibodies. MVD for CD105 increased significantly during tumor progression, whereas this was not the case for CD34 MVD. Comparing widely invasive CXPA with and without myoepithelial differentiation, CXPA with myoepithelial differentiation showed a significantly lower number of CD105 positive vessels but revealed higher TVA values. In these tumors, the neoplastic cells usually formed larger hypovascularized aggregates that were often surrounded by large-sized vessels. In conclusion, the antibody CD105 reveals an angiogenic switch during the progression from adenoma to carcinoma in salivary glands. The degree of angiogenesis and the total vascular area have distinctive patterns in CXPA with and without myoepithelial differentiation. Low angiogenesis associated with high TVA value is more characteristic of CXPA with myoepithelial differentiation. (AU)

Processo FAPESP: 04/07960-0 - Estudo das alterações ocorridas no adenoma durante o processo de malignização em carcinoma ex-adenoma pleomórfico
Beneficiário:Vera Cavalcanti de Araujo
Modalidade de apoio: Auxílio à Pesquisa - Temático