Synthesis, spectroscopic characterizations and antimicrobial activity of copper and zinc complexes of levofloxacin, ciprofloxacin and 3-carboxy-4-quinolone

Autor(es)

Huber, Paula C. ^[1] ; Reis, Gabriella P. ^[1] ; Amstalden, Maria C. K. ^[2] ; Lancellotti, Marcelo ^[2] ; Almeida, Wanda P. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Estadual Campinas, Inst Chem, Lab Drug Design, BR-13083970 Campinas, SP - Brazil

^[2] Univ Estadual Campinas, Inst Biol, Biotechnol Lab, BR-13083970 Campinas, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Polyhedron; v. 57, p. 14-19, JUL 2 2013.
• Citações Web of Science: 12

Resumo

Copper and zinc complexes based on levofloxacin, ciprofloxacin and 3-carboxy-4-quinolone with molecular formula IM(C18H19FN3O4)(2)].2H(2)O, {[}M(C-17 H17FN3O3)(2)].2H(2)O and {[}M(C10H6NO3)].2H2O, respectively, were synthesized by the reaction of copper or zinc nitrate and the corresponding ligand. Complexes were not obtained as single crystals. Infrared spectroscopy, high resolution mass spectrometry and thermogravimetric analysis are also performed. Except in the case of copper complexes, H-1 and C-13 NMR spectra were obtained. Antimicrobial activity of complexes and their ligands are carried out against a panel of microorganism from ATCC cultures and strains from clinical isolate were also included. All complexes showed moderate to good antimicrobial activity depending on the concentration. (C) 2013 Elsevier Ltd. All rights reserved. (AU)

• Processo FAPESP: 11/21693-9 - Síntese de complexos de cobre e zinco e a fluorquinolona levofloxacina, potencial candidato a fármaco para o tratamento da Doença de Alzheimer
• Beneficiário: Gabriella Pitondo Reis
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica
• Processo FAPESP: 10/20861-2 - Desenvolvimento de candidatos a fármacos para o tratamento da doença de Alzheimer. I. Investigação de quelantes de metais como agentes inibidores da agregação do peptídeo beta-amilóide; II. Desenvolvimento de híbridos da tacrina e ibuprofeno
• Beneficiário: Wanda Pereira Almeida
• Modalidade de apoio: Auxílio à Pesquisa - Regular