Synthesis, spectroscopic characterizations and antimicrobial activity of copper and zinc complexes of levofloxacin, ciprofloxacin and 3-carboxy-4-quinolone

Author(s)

Huber, Paula C. ^[1] ; Reis, Gabriella P. ^[1] ; Amstalden, Maria C. K. ^[2] ; Lancellotti, Marcelo ^[2] ; Almeida, Wanda P. ^[1]

Affiliation

^[1] Univ Estadual Campinas, Inst Chem, Lab Drug Design, BR-13083970 Campinas, SP - Brazil

^[2] Univ Estadual Campinas, Inst Biol, Biotechnol Lab, BR-13083970 Campinas, SP - Brazil

• Document type: Journal article
• Source: Polyhedron; v. 57, p. 14-19, JUL 2 2013.
• Web of Science Citations: 12

Abstract

Copper and zinc complexes based on levofloxacin, ciprofloxacin and 3-carboxy-4-quinolone with molecular formula IM(C18H19FN3O4)(2)].2H(2)O, {[}M(C-17 H17FN3O3)(2)].2H(2)O and {[}M(C10H6NO3)].2H2O, respectively, were synthesized by the reaction of copper or zinc nitrate and the corresponding ligand. Complexes were not obtained as single crystals. Infrared spectroscopy, high resolution mass spectrometry and thermogravimetric analysis are also performed. Except in the case of copper complexes, H-1 and C-13 NMR spectra were obtained. Antimicrobial activity of complexes and their ligands are carried out against a panel of microorganism from ATCC cultures and strains from clinical isolate were also included. All complexes showed moderate to good antimicrobial activity depending on the concentration. (C) 2013 Elsevier Ltd. All rights reserved. (AU)

• FAPESP's process: 11/21693-9 - Synthesis of copper and zinc complexes of levofloxacin, a potential drug candidate to treat Alzheimer's Disease
• Grantee: Gabriella Pitondo Reis
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• FAPESP's process: 10/20861-2 - Development of candidate drugs for the treatment of Alzheimer's disease. I. investigation of metal chelators as inhibitors of the beta-amyloid aggregation; II. Development of tacrine-ibuprofen hybrids
• Grantee: Wanda Pereira Almeida
• Support Opportunities: Regular Research Grants