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Synthesis of New Ag(I), Cu(II), Pd(II) and Pt(II) complexes based on sulfonamides and derivatives: antibacterial activities and application prospects on skin critically colonized wounds.

Grant number: 15/25114-4
Support Opportunities:Regular Research Grants
Duration: March 01, 2016 - February 28, 2018
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Inorganic Chemistry
Principal Investigator:Pedro Paulo Corbi
Grantee:Pedro Paulo Corbi
Host Institution: Instituto de Química (IQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil

Abstract

The discovery and the rational use of antimicrobial agents in the treatment of several infections brought a significant improvement in the life quality of patients. However, the indiscriminate use antimicrobial agents, including sulfonamides, has led to the appearance of multi-resistant bacterial strains, leading to the search for new drugs. One of the strategies to develop new antibacterial agents, especially for topical use, is to combine the existing drugs with metal ions having recognized antibacterial activity such as silver(I), copper(II) platinum(II) and palladium(II). Within this context, this project aims the synthesis, characterization and studies of the antibacterial activities of metal complexes of Ag(I), Cu(II), Pt(II) and Pd(II) with the sulfonamides sulfasalazine, sulfisoxazole and acetazolamide. The synthesized complexes will be characterized by a set of chemical and spectroscopic analysis, with emphasis on infrared spectroscopy, nuclear magnetic resonance of 1H, 13C and 15N, and high resolution mass spectrometry. The antibacterial activity of the compounds will be first evaluated by disc diffusion method (antibiogram). Subsequently the active compounds will be evaluated to determine their minimum inhibitory concentrations (MIC). Finally, these complexes will be impregnated in biocompatible carriers, to evaluate the drug release capacity and the preparation of controlled release devices of new antibacterial agents for topical use. (AU)

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Scientific publications (29)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
BERGAMINI, FERNANDO R. G.; NUNES, JULIA H. B.; MANZANO, CARLOS MARROTE; DE CARVALHO, MARCOS ALBERTO; RIBEIRO, MARCOS ANTONIO; RUIZ, ANA LUCIA TASCA GOIS; DE CARVALHO, JOAO ERNESTO; LUSTRI, WILTON ROGERIO; DE PAIVA, RAPHAEL ENOQUE FERRAZ; PORTES, MARCELO CECCONI; et al. Investigating the antiproliferative activities of new Cu-II complexes with pyridine hydrazone derivatives of nalidixic acid. Journal of Inorganic Biochemistry, v. 234, p. 11-pg., . (21/08717-8, 13/07937-8, 18/12590-0, 17/25995-6, 15/25114-4, 18/12062-4)
BORMIO NUNES, JULIA H.; DE PAIVA, PAULA P.; RUIZ, ANA LUCIA T. G.; DE CARVALHO, JOAO ERNESTO; CORBI, PEDRO P.. New findings on the antiproliferative activity of the silver(I) complex with 5-fluorouracil against human multi-resistant NCI/ADR-RES ovarian tumor cells. TOXICOLOGY IN VITRO, v. 60, p. 359-368, . (18/12062-4, 15/25114-4)
YAMAMOTO, LAIS MEGUMI; BORMIO NUNES, JULIA HELENA; RIBEIRO, MARCOS ANTONIO; DA COSTA FERREIRA, ANA MARIA; LUSTRI, WILTON ROGERIO; CORBI, PEDRO PAULO. Copper(II) and silver(I) complexes with sulfamethizole: synthesis, spectroscopic characterization, ESI-QTOF mass spectrometric analysis, crystal structure and antibacterial activities. Polyhedron, v. 138, p. 168-176, . (15/09833-0, 16/01579-0, 15/25114-4)
FIORI-DUARTE, ANA THEREZA; BERGAMINI, FERNANDO R. G.; DE PAIVA, RAPHAEL ENOQUE E.; MANZANO, CARLOS M.; LUSTRI, WILTON R.; CORBI, PEDRO P.. A new palladium(II) complex with ibuprofen: Spectroscopic characterization, DFT studies, antibacterial activities and interaction with biomolecules. Journal of Molecular Structure, v. 1186, p. 144-154, . (18/12062-4, 15/25114-4, 10/00667-7, 17/25995-6, 15/09833-0)
BORMIO NUNES, JULIA H.; SIMONI, DEBORAH A.; BRAGA, LUCIA E. O.; RUIZ, ANA LUCIA T. G.; DE CARVALHO, JOAO ERNESTO; CORBI, PEDRO P.. Synthesis, characterization, crystal structure and in vitro antiproliferative assays of the 2-thiouracilato(triphenylphosphine) gold(I) complex. Journal of Molecular Structure, v. 1178, p. 169-178, . (15/25114-4)
BORMIO NUNES, JULIA H.; DE PAIVA, PAULA P.; RUIZ, ANA LUCIA T. G.; DE CARVALHO, JOAO ERNESTO; CORBI, PEDRO P.. A platinum(II) complex with the antitumor drug 5-fluorouracil: synthesis, spectroscopic characterization and biological assays. JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY, v. 22, p. 1-pg., . (15/25114-4)
NAKAHATA, DOUGLAS HIDEKI; FERRAZ DE PAIVA, RAPHAEL ENOQUE; LUSTRI, WILTON ROGERIO; RIBEIRO, CAMILA MARINGOLO; PAVAN, FERNANDO ROGERIO; CORBI, PEDRO PAULO. Copper(II) complexes with sulfonamides: crystal structures, biophysical assays and antimycobacterial activity. JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY, v. 22, p. 1-pg., . (15/20882-3, 15/25114-4, 15/09833-0)
LAZARINI, SILMARA CRISTINA; CORBI, PEDRO PAULO; LUSTRI, WILTON ROGERIO. Release capacity in bacterial cellulose membranes of antibacterial Ag(I) metal complex with furosemide. JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY, v. 22, p. 1-pg., . (15/25114-4, 15/09833-0)
FERRAZ DE PAIVA, RAPHAEL ENOQUE; NAKAHATA, DOUGLAS HIDEKI; CORBI, PEDRO PAULO. Synthesis and crystal structure of dichlorido(1,10-phenanthroline-kappa N-2,N `)gold(III) hexafluoridophosphate. ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS, v. 73, n. 7, p. 1048+, . (15/25114-4, 15/20882-3)
CIOL, MARIANA ROSOLEN; MANZANO, CARLOS MARROTE; CUIN, ALEXANDRE; PAVAN, FERNANDO ROGERIO; RIBEIRO, CAMILA MARINGOLO; TASCA GOIS RUIZ, ANA LUCIA; DE OLIVEIRA, ELLEN CRISTINA S.; LUSTRI, WILTON ROGERIO; FREGONEZI, NATHALIA FERREIRA; RESENDE NOGUEIRA, FLAVIA APARECIDA; et al. A Silver Complex with Cycloserine: Synthesis, Spectroscopic Characterization, Crystal Structure and In Vitro Biological Studies. CHEMISTRYSELECT, v. 3, n. 6, p. 1719-1726, . (15/09833-0, 15/25114-4)
BORMIO NUNES, JULIA H.; BERGAMINI, FERNANDO R. G.; LUSTRI, WILTON R.; DE PAIVA, PAULA P.; RUIZ, ANA LUCIA T. G.; DE CARVALHO, JOAO ERNESTO; CORBI, PEDRO P.. Synthesis, characterization and in vitro biological assays of a silver(I) complex with 5-fluorouracil: A strategy to overcome multidrug resistant tumor cells. JOURNAL OF FLUORINE CHEMISTRY, v. 195, p. 93-101, . (15/25114-4)
LUSTRI, WILTON R.; LAZARINI, SILMARA C.; LUSTRI, BRUNA CARDINALI; CORBI, PEDRO P.; SILVA, MARIA ALINE C.; RESENDE NOGUEIRA, FLAVIA APARECIDA; AQUINO, RENATA; AMARAL, ANDRE C.; TREU FILHO, OSWALDO; MASSABNI, ANTONIO CARLOS; et al. Spectroscopic characterization and biological studies in vitro of a new silver complex with furosemide: Prospective of application as an antimicrobial agent. Journal of Molecular Structure, v. 1134, p. 386-394, . (15/09833-0, 15/25114-4, 12/08230-2)
BERGAMINI, FERNANDO R. G.; NUNES, JULIA H. B.; DE CARVALHO, MARCOS A.; RIBEIRO, MARCOS A.; DE PAIVA, PAULA P.; BANZATO, THAIS P.; RUIZ, ANA L. T. G.; DE CARVALHO, JOAO E.; LUSTRI, WILTON R.; MARTINS, DANIEL O. T. A.; et al. Polynuclear copper(II) complexes with nalidixic acid hydrazones: Antiproliferative activity and selectivity assessment over a panel of tumor cells. Inorganica Chimica Acta, v. 484, p. 491-502, . (15/25114-4)
FERRAZ DE PAIVA, RAPHAEL ENOQUE; NAKAHATA, DOUGLAS HIDEKI; DE CARVALHO, MARCOS ALBERTO; GOULART BERGAMINI, FERNANDO RODRIGUES; CORBI, PEDRO PAULO. N,N `,N `' versus N,N `,O imine-containing coordination motifs: ligand-directed synthesis of mono-nuclear and binuclear Cu-II compounds. ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS, v. 73, n. 10, p. 1563+, . (15/25114-4, 15/20882-3)
NAKAHATA, DOUGLAS H.; DE PAIVA, RAPHAEL E. F.; LUSTRI, WILTON R.; RIBEIRO, CAMILA M.; PAVAN, FERNANDO R.; DA SILVA, GISELE G.; RUIZ, ANA L. T. G.; DE CARVALHO, JOAO E.; CORBI, PEDRO P.. Sulfonamide-containing copper(II) metallonucleases: Correlations with in vitro antimycobacterial and antiproliferative activities. Journal of Inorganic Biochemistry, v. 187, p. 85-96, . (15/09833-0, 15/25114-4, 15/20882-3)
MANZANO, CARLOS M.; BERGAMINI, FERNANDO R. G.; LUSTRI, WILTON R.; RUIZ, ANA LUCIA T. G.; DE OLIVEIRA, ELLEN C. S.; RIBEIRO, MARCOS A.; FORMIGA, ANDRE L. B.; CORBI, PEDRO P.. Pt(II) and Pd(II) complexes with ibuprofen hydrazide: Characterization, theoretical calculations, antibacterial and antitumor assays and studies of interaction with CT-DNA. Journal of Molecular Structure, v. 1154, p. 469-479, . (15/25114-4, 13/22127-2)
NAKAHATA, DOUGLAS H.; RIBEIRO, MARCOS A.; CORBI, PEDRO P.; MACHADO, DAISY; LANCELLOTTI, MARCELO; LUSTRI, WILTON R.; DA COSTA FERREIRA, ANA M.; FORMIGA, ANDRE L. B.. Synthesis, characterization and preliminary antimicrobial assays of copper(II) complexes with 2-(imidazole-2-yl)heteroaryl ligands. Inorganica Chimica Acta, v. 458, p. 224-232, . (15/25114-4)
SIMEI AQUARONI, NAYARA APARECIDA; NAKAHATA, DOUGLAS HIDEKI; CORBI, PEDRO PAULO; LUSTRI, WILTON ROGERIO. Antibacterial activities of a Ag(I) complex with 4-aminobenzoic acid. JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY, v. 22, p. 1-pg., . (15/20882-3, 15/25114-4, 15/09833-0)
DE PAIVA, RAPHAEL E. F.; DU, ZHIFENG; NAKAHATA, DOUGLAS H.; CORBI, PEDRO P.; PETERSON, ERICA J.; FARRELL, NICHOLAS P.. S-arylation: A unique zinc finger inhibition mechanism observed for Au(2-benzylpyridine)Cl-2. JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY, v. 22, p. 1-pg., . (15/25114-4)
CIOL, MARIANA ROSOLEN; MANZANO, CARLOS MARROTE; CUIN, ALEXANDRE; PAVAN, FERNANDO ROGERIO; RIBEIRO, CAMILA MARINGOLO; CORBI, PEDRO PAULO. A novel silver complex with cycloserine.. JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY, v. 22, p. 1-pg., . (15/25114-4)
LUSTRI, WILTON ROGERIO; NAKAHATA, DOUGLAS HIDEKI; CORBI, PEDRO PAULO; LAZARINI, SILMARA CRISTINA; TROVATTI, ELIANE. 1-Hydroxibenzotriazole-silver complex: synthesis and biological activities. JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY, v. 22, p. 1-pg., . (15/25114-4, 15/09833-0)
NAKAHATA, DOUGLAS H.; DE PAIVA, RAPHAEL E. F.; LUSTRI, WILTON R.; CORBI, PEDRO P.. Sulfonamide-containing copper(ii) complexes: new insights on biophysical interactions and antibacterial activities. NEW JOURNAL OF CHEMISTRY, v. 44, n. 40, p. 9-pg., . (15/09833-0, 15/20882-3, 18/12062-4, 18/21537-6, 18/12590-0, 15/25114-4)
FERRAZ DE PAIVA, RAPHAEL ENOQUE; NAKAHATA, DOUGLAS HIDEKI; CORBI, PEDRO PAULO. Synthesis and crystal structure of dichlorido(1,10-phenanthroline-kappa N-2,N ')gold(III) hexafluoridophosphate. ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS, v. 73, p. 8-pg., . (15/20882-3, 15/25114-4)
FERRAZ DE PAIVA, RAPHAEL ENOQUE; NAKAHATA, DOUGLAS HIDEKI; DE CARVALHO, MARCOS ALBERTO; GOULART BERGAMINI, FERNANDO RODRIGUES; CORBI, PEDRO PAULO. N,N ',N '' versus N,N ',O imine-containing coordination motifs: ligand-directed synthesis of mono-nuclear and binuclear Cu-II compounds. ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS, v. 73, p. 14-pg., . (15/20882-3, 15/25114-4)
FIORI, ANA THEREZA M.; NAKAHATA, DOUGLAS H.; CUIN, ALEXANDRE; LUSTRI, WILTON R.; CORBI, PEDRO P.. Synthesis, crystallographic studies, high resolution mass spectrometric analyses and antibacterial assays of silver(I) complexes with sulfisoxazole and sulfadimethoxine. Polyhedron, v. 121, p. 172-179, . (15/09833-0, 15/25114-4, 15/20882-3)
NAKAHATA, DOUGLAS H.; LUSTRI, WILTON R.; CUIN, ALEXANDRE; CORBI, PEDRO P.. Crystal structure, spectroscopic characterization and antibacterial activities of a silver complex with sulfameter. Journal of Molecular Structure, v. 1125, p. 609-615, . (15/09833-0, 15/25114-4, 15/20882-3)
AMARAL, THAENY C.; MIGUEL, FABIO B.; COURI, MARA R. C.; CORBI, PEDRO P.; CARVALHO, MARCOS A.; CAMPOS, DEBORA L.; PAVAN, FERNANDO R.; CUIN, ALEXANDRE. Silver(I) and zinc(II) complexes with symmetrical cinnamaldehyde Schiff base derivative: Spectroscopic, powder diffraction characterization, and antimycobacterial studies. Polyhedron, v. 146, p. 166-171, . (15/25114-4)
DE PAIVA, RAPHAEL E. F.; DU, ZHIFENG; NAKAHATA, DOUGLAS H.; LIMA, FREDERICO A.; CORBI, PEDRO P.; FARRELL, NICHOLAS P.. Gold-Catalyzed C-S Aryl-Group Transfer in Zinc Finger Proteins. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, v. 57, n. 30, p. 9305-9309, . (15/25114-4, 15/20882-3)

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Filed patent(s) as a result of this research project

PROCESSO DE OBTENÇÃO DOS DISPOSITIVOS DE CB-AG-NMS E CB-AG-pABA, DISPOSITIVOS DE CB-AG-NMS E CB-AG-pABA E USO DOS DISPOSITIVOS CB-AG-NMS E CB-AG-pABA PCT/BR2020/050434 - UNIARA ; Universidade Estadual de Campinas (UNICAMP) . Tuany Zambroti Cândido ; Raphael Enoque Ferraz de Paiva ; Silmara Cristina Lazarini Frajácomo ; Douglas Hideki Nakahata ; Nayara Aparecida Simei Aquaroni ; Carmen Silvia Passos Lima ; Pedro Paulo Corbi ; Wilton Rogério Lustri ; Ana Lucia Tasca Góis Ruiz ; Karin Maia Monteiro ; João Ernesto de Carvalho ; Camilla Abbehausen - October 2020, 23