Synthesis, characterization and antibacterial activity studies of Ag (i) and Cu (II) complexes with sulfamethizole

• Grant number: 16/01579-0
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: April 01, 2016
• End date: August 22, 2017
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Inorganic Chemistry
• Principal Investigator: Pedro Paulo Corbi
• Grantee: Lais Megumi Yamamoto
• Host Institution: Instituto de Química (IQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil

Abstract

Metal complexes have various medical applications, not only for the diagnosis but also for the treatment of diseases. For example, complexes of aluminum are used as antacids, complexes of copper have fungicide activities, complexes of gadolinium are used as contrast agents and complexes of platinum are used in the treatment of cancer. The scope of this project is the synthesis of new Ag (I) and Cu (II) complexes with sulfamethizole, a drug from the class of sulfonamides with antibacterial action. The obtained compounds will be synthesized by reactions in aqueous or alcoholic solution and characterized using several techniques, especially thermal and elementar analysis, nuclear magnetic resonance spectroscopy of 1H, 13C and 15N, infrared spectroscopy and mass spectrometry. The antibacterial activities of the complexes obtained will also be performed using methods described in the literature and already applied in our research group.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

YAMAMOTO, LAIS MEGUMI; BORMIO NUNES, JULIA HELENA; RIBEIRO, MARCOS ANTONIO; DA COSTA FERREIRA, ANA MARIA; LUSTRI, WILTON ROGERIO; CORBI, PEDRO PAULO. Copper(II) and silver(I) complexes with sulfamethizole: synthesis, spectroscopic characterization, ESI-QTOF mass spectrometric analysis, crystal structure and antibacterial activities. Polyhedron, v. 138, p. 168-176, DEC 14 2017. (15/09833-0, 16/01579-0, 15/25114-4)