Synthesis, characterization and studies of the antibacterial activities of Ag(I), Cu(II) and Pt(II) complexes with sulfamethazine

• Grant number: 18/09860-6
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: July 01, 2018
• End date: June 30, 2019
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Inorganic Chemistry
• Principal Investigator: Pedro Paulo Corbi
• Grantee: Bianca Alves Schimitd
• Host Institution: Instituto de Química (IQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil

Abstract

Metal complexes are currently used in medicine for both diagnosis and treatment of diseases. There are known, for example, the applications of technetium complexes as diagnostic agents for tumors, gold complexes in the treatment of rheumatoid arthritis, platinum(II) complexes as antitumoral agents, silver complexes as antimicrobial agents, lithium complexes in the treatment of disorders psychiatric and iron(III) complexes as antihypertensives. More specifically, due to the growth of bacterial resistance to antibiotics available on the market, the search for active drugs on multiresistant strains has been the target of several research groups worldwide. One strategy that has shown to be promising in our research group is the combination of drugs already consolidated in the market and actives on microorganisms and metals with recognized antimicrobial activities.Thus, in this project the synthesis of Ag(I), Cu(II) and Pt(II) complexes with sulfamethazine, a commercially available antibacterial drug, is envisaged. The compounds will be prepared from the reaction of the metal salts of interest and the commercial ligands by varying the synthesis conditions as solvent, pH and temperature, and will be characterized by techniques such as 1H and 13C nuclear magnetic resonance, infrared spectroscopy and mass spectrometry, X-ray diffraction and thermal analysis (TG / DTA). Biological assays will be performed to analyze the antibacterial activities of the compounds, as well as the interaction of compounds that are active with biomolecules such as proteins and DNA.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

QUINTANILHA, MARIANA MAZZO; SCHIMITD, BIANCA ALVES; COSTA, ADAO MARCOS FERREIRA; NAKAHATA, DOUGLAS HIDEKI; SIMONI, DEBORAH DE ALENCAR; CLAVIJO, JUAN CARLOS TENORIO; PEREIRA, DOUGLAS HENRIQUE; MASSABNI, ANTONIO CARLOS; LUSTRI, WILTON ROGERIO; CORBI, PEDRO PAULO. A novel water-soluble platinum(II) complex with the amino acid deoxyalliin: synthesis, crystal structure, theoretical studies and investigations about its antibacterial activity. Journal of Molecular Structure, v. 1236, JUL 15 2021. (13/08293-7, 15/20882-3, 18/09860-6, 18/09856-9, 18/12590-0, 15/09833-0, 18/12062-4, 17/11485-6)