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Synthesis, characterization and antibacterial assays of new Ag(I) and Cu(II) complexes with acetazolamide

Grant number: 15/09531-4
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): July 01, 2015
Effective date (End): June 30, 2016
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Inorganic Chemistry
Principal Investigator:Pedro Paulo Corbi
Grantee:Caroline Santos Andrade
Home Institution: Instituto de Química (IQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil

Abstract

In the last years, the indiscriminate use of medicines and the constant act of self-medication increased the concern about the existence of multi-resistant bacteria to the antibiotics. So, the studies on synthesis of new metallopharmaceutical agents that may have more efficacy than those used in the clinics are of great interest. In this context, the sulfa drugs become even more interesting, especially due to its bacteriostatic activities and the number of new compounds that can be created from them, such as the metallic complexes. In this subject, two elements deserve attention by their antimicrobial activities: copper and silver. This project aims to synthesize and characterize new complexes of silver(I) and copper(II) with acetazolamide and the study of the antibacterial activity of such compounds over Gram-positive and Gram-negative bacterial strains.