Energy deposition in small-scale targets of liquid water using the very low energy electromagnetic physics processes of the Geant4 toolkit

Autor(es)

Incerti, S. ^[1] ; Champion, C. ^[1] ; Tran, H. N. ^[1] ; Karamitros, M. ^[2] ; Bernal, M. ^[2] ; Francis, Z. ^[3] ; Ivanchenko, V. ^[4] ; Mantero, A. ^[5] ; Collaboration, Geant4-DNA

Afiliação do(s) autor(es)

^[1] Univ Bordeaux 1, CNRS IN2P3, CENBG, F-33175 Gradignan - France

^[2] Univ Estadual Campinas, Inst Fis Gleb Wataghin, BR-13081970 Campinas, SP - Brazil

^[3] Univ St Joseph, Fac Sci, Dept Phys, Beirut - Lebanon

^[4] Ecoanalytica, Moscow 119899 - Russia

^[5] Ist Nazl Fis Nucl, Sez Genova, I-16146 Genoa - Italy

• Tipo de documento: Artigo Científico
• Fonte: NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIO; v. 306, p. 158-164, JUL 1 2013.
• Citações Web of Science: 26

Resumo

In the perspective of building an open source simulation platform dedicated to the modelling of early biological molecular damages due to ionising radiation at the DNA scale, the general-purpose Geant4 Monte Carlo simulation toolkit has been recently extended with specific very low energy electromagnetic physics processes for liquid water medium. These processes - also called ``Geant4-DNA{''} processes - simulate the physical interactions induced by electrons, hydrogen and helium atoms of different charge states. The present work reports on the energy deposit distributions obtained for incident electrons, protons and alpha particles in nanometre-size volumes comparable to those present in the genetic material of mammalian cells. The frequency distributions of the energy deposition obtained for three typical geometries of nanometre-size cylindrical targets placed in a spherical phantom are found to be in reasonable agreement with prior works. Furthermore, we present a combination of the Geant4-DNA processes with a simplified geometrical model of a cellular nucleus allowing the evaluation of energy deposits in volumes of biological interest. (C) 2013 Elsevier B.V. All rights reserved. (AU)

• Processo FAPESP: 11/51594-2 - Desenvolvimento de um sistema computacional para a simulação da interação da radiação ionizante com o material genético humano
• Beneficiário: Mario Antonio Bernal Rodriguez
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores