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The Prevalence of Iron Deficiency Anemia in Primary Antiphospholipid Syndrome

Texto completo
Autor(es):
Klack, Karin [1] ; Monma, Vanessa [1] ; Pelicari, Karina [2] ; Appenzeller, Simone [2] ; de Carvalho, Jozelio Freire [3]
Número total de Autores: 5
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Fac Med, Hosp Clin, Div Nutr, Sao Paulo - Brazil
[2] State Univ Campinas UNICAMP, Fac Med Sci, Dept Med, Div Rheumatol, Campinas, SP - Brazil
[3] Univ Sao Paulo, Fac Med, Hosp Clin, Div Rheumatol, Sao Paulo - Brazil
Número total de Afiliações: 3
Tipo de documento: Artigo Científico
Fonte: Turkish Journal of Rheumatology; v. 28, n. 2, p. 96-100, 2013.
Citações Web of Science: 0
Resumo

Objectives: The aim of this study was to evaluate the prevalence of subclinical and clinical iron deficiency with iron deficiency anemia in primary antiphospholipid syndrome (PAPS). Patients and methods: The study was comprised of 29 PAPS patients and 29 healthy controls matched for age, gender, and socioeconomic status. Participants received iron, folic acid, vitamin B12, and vitamin C. A battery of tests was performed to determine the iron storage. The mean disease duration was 70 +/- 51.3 months in the patient group. Results: Iron storage depletion was observed in 10.3% of the individuals in both groups (p= 0.5). Iron deficient erythropoiesis (IDE) was observed in only three PAPS patients (10.3%) (p<0.001). Iron deficiency anemia (IDA) was more common in the PAPS patients compared to controls (48.2% vs. 10.3%, respectively; p=0.009). The mean iron levels were significantly lower in the PAPS group than the controls (75.5 vs. 95.8, respectively; p=0.03). Red cell distribution width-coefficient of variation (RDW-CV) (14.9 vs. 13.2; p= 0.02) and red cell distribution width-standard deviation (RDW-SD) (46.7 vs. 40.5; p= 0.009) were significantly increased in the patient group. The folic acid and vitamin C levels were lower in the PAPS group than the control group (p<0.05). Conclusion: This study showed for the first time that PAPS patients have a higher incidence of IDA and IDE compared to healthy controls. This can be attributed to inadequate ingestion of folic acid and vitamin C. (AU)

Processo FAPESP: 09/06049-6 - Determinação de marcadores séricos e do líquor associados a alterações estruturais e funcionais do sistema nervoso central no Lúpus eritematoso sistêmico
Beneficiário:Simone Appenzeller
Linha de fomento: Bolsas no Brasil - Apoio a Jovens Pesquisadores
Processo FAPESP: 08/02917-0 - Determinação de marcadores séricos e do líquor associados a alterações estruturais e funcionais do sistema nervoso central no lúpus eritematoso sistêmico
Beneficiário:Simone Appenzeller
Linha de fomento: Auxílio à Pesquisa - Apoio a Jovens Pesquisadores