| Texto completo | |
| Autor(es): |
Zuleta, Luz Margarita Cardona
;
Cavalheiro, Alberto José
;
Silva, Dulce Helena Siqueira
;
Furlan, Maysa
;
Young, Maria Claudia Marx
;
Albuquerque, Sérgio
;
Castro-Gamboa, Ian
;
Bolzani, Vanderlan da Silva
[8]
Número total de Autores: 8
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Phytochemistry; v. 64, n. 2, p. 549-553, Sept. 2003. |
| Área do conhecimento: | Ciências Exatas e da Terra - Química |
| Assunto(s): | Iridoides Rubiaceae Antiparasitários |
| Resumo | |
Three seco-iridoids 7-methoxydiderroside, 6'-O-acetyldiderroside and 8-O-tigloyldiderroside, were isolated from the wood bark of Calycophyllum spruceanum together with the known iridoids loganetin, loganin and the seco-iridoids secoxyloganin, kingiside and diderroside. Their structures were elucidated by means of NMR and MS spectral data analysis. Using NOE correlations and coupling constants, the relative stereochemistry of the new derivatives was established. 7-Methoxydiderroside, 6'-O-acetyldiderroside and the known secoxyloganin and diderroside showed in vitro activity against trypomastigote forms of Trypanosoma cruzi, with IC50 values of 59.0, 90.2, 74,2 and 84.9 ug/mL, respectively and were compared to the standard gentian violet (IC50 7.5 ug/ml). Three seco-iridoids 7-methoxydiderroside, 6'-O-acetyldiderroside and 8-O-tigloyldiderroside, were isolated from the wood bark of Calycophyllum spruceanum together with the known iridoids loganetin, loganin and the seco-iridoids secoxyloganin, kingiside and diderroside. Some of these micromolecules showed weak in vitro activity against trypomastigote forms of Trypanosoma cruzi. (AU) | |
| Processo FAPESP: | 98/05074-0 - Conservação e uso sustentável da biodiversidade vegetal do Cerrado e da Mata Atlântica: diversidade química e prospecção de medicamentos potenciais |
| Beneficiário: | Vanderlan da Silva Bolzani |
| Modalidade de apoio: | Auxílio à Pesquisa - Programa BIOTA - Temático |