Determination of propylthiouracil in pharmaceuticals by differential pulse voltammetry using a cathodically pretreated boron-doped diamond electrode

Autor(es)

Elen Romão Sartori ; Aline Barrios Trench ^[2] ; Romeu C. Rocha-Filho ^[2] ; Orlando Fatibello-Filho ^[2]

• Tipo de documento: Artigo Científico
• Fonte: Journal of the Brazilian Chemical Society; v. 24, n. 9, p. 1504-1511, 2013-09-00.

Resumo

A simple procedure is described for the determination of propylthiouracil (PTU) by differential pulse voltammetry (DPV) using a cathodically pretreated boron-doped diamond (BDD) electrode. Cyclic voltammetry studies indicate that the oxidation of PTU is irreversible at a peak potential of 1.42 V (vs. Ag/AgCl (3.0 mol L-1 KCl)) in a Britton-Robinson (BR) buffer solution (pH 2.0). Under optimized conditions, the obtained analytical curve was linear (r = 0.9985) for the PTU concentration range of 1.0 to 29.1 mmol L-1 in a BR buffer solution (pH 2.0), with a detection limit of 0.90 mmol L-1. The proposed method was successfully applied in the determination of PTU in pharmaceutical samples, with results in agreement at a 95% confidence level with those obtained using an official titration method. (AU)

• Processo FAPESP: 09/14454-8 - Eletrodos de carbono modificados com nanotubos de carbono e/ou nanopartículas metálicas em filmes de quitosana para a determinação de compostos de enxofre em derivados de petróleo e alimentos
• Beneficiário: Elen Julciléia Romão Sartori
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado