Mammary analogue secretory carcinoma of salivary glands is a lipid-rich tumour, and adipophilin can be valuable in its identification

Autor(es)

Mariano, Fernanda Viviane ^[1] ; dos Santos, Harim Tavares ^[2] ; Delgado Azanero, Wilson ^[3] ; da Cunha, Isabela Werneck ^[4] ; Coutinho-Camilo, Claudia Malheiros ^[4] ; de Almeida, Oslei Paes ^[2] ; Kowalski, Luiz Paulo ^[5] ; Altemani, Albina ^[1]

Afiliação do(s) autor(es)

^[1] Univ Campinas UNICAMP, Fac Med Sci, Dept Pathol, Campinas, SP - Brazil

^[2] Univ Campinas UNICAMP, Piracicaba Dent Sch, Dept Oral Pathol, Piracicaba - Brazil

^[3] Peruvian Univ Cayetano Heredia, Dept Oral Pathol Med & Surg, Lima - Peru

^[4] AC Camargo Hosp, Dept Pathol, Sao Paulo - Brazil

^[5] AC Camargo Hosp, Dept Head & Neck & Otorhinolaryngol, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Histopathology; v. 63, n. 4, p. 558-567, OCT 2013.
• Citações Web of Science: 29

Resumo

AimsMammary analogue secretory carcinoma (MASC) of salivary glands shows morphological similarities to milk-secreting mammary epithelial cells. The aim of this study was to analyse the immunohistochemical expression of adipophilin (a component of milk lipid globule membranes) and of proteins related to secretory mechanisms (STAT5a and mammaglobin) in MASC and other salivary tumours. Methods and resultsTen cases of MASC (all with ETV6 translocation) and 83 other salivary carcinomas were studied. In all MASC cases, adipophilin stained numerous large lipid droplets. These droplets were minute in other salivary carcinomas, except for sebaceous carcinoma. Overexpression of STAT5a was detected in all MASC cases, but only occasionally in other carcinomas. Mammaglobin expression occurred frequently in MASC (70% of cases), whereas, in other carcinomas, it was uncommon and limited. Only MASC showed cytoplasmic reactivity for p63, particularly in papillary-cystic areas. Positivity for S100, vimentin and high molecular weight keratin was observed in 100% of MASC cases. ConclusionsMASC is a lipid-rich tumour containing large lipid droplets covered by adipophilin. This finding can be included among its defining immunohistochemical features, and possibly represents lactation-like secretory differentiation. Strong expression of STAT5a and cytoplasmic p63 in MASC reinforces this hypothesis. (AU)

• Processo FAPESP: 12/18086-6 - Gotas lipídicas intracitoplasmáticas em tumores de glândulas salivares: estudo imunohistoquímico
• Beneficiário: Albina Messias de Almeida Milani Altemani
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 11/23204-5 - Estudo do perfil genômico do carcinoma ex-adenoma pleomorfo por hibridização genômica comparativa em microarranjo (CGH array)
• Beneficiário: Albina Messias de Almeida Milani Altemani
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 11/23366-5 - Estudo do perfil genômico do carcinoma ex-adenoma pleomorfo por hibridização genômica comparativa em microarranjo (CGH array)
• Beneficiário: Fernanda Viviane Mariano Brum Corrêa
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 12/18104-4 - Gotas lipídicas intracitoplasmáticas em tumores de glândulas salivares. Estudo imunohistoquímico
• Beneficiário: Harim Tavares dos Santos
• Modalidade de apoio: Bolsas no Brasil - Mestrado