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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Mammary analogue secretory carcinoma of salivary glands is a lipid-rich tumour, and adipophilin can be valuable in its identification

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Author(s):
Mariano, Fernanda Viviane [1] ; dos Santos, Harim Tavares [2] ; Delgado Azanero, Wilson [3] ; da Cunha, Isabela Werneck [4] ; Coutinho-Camilo, Claudia Malheiros [4] ; de Almeida, Oslei Paes [2] ; Kowalski, Luiz Paulo [5] ; Altemani, Albina [1]
Total Authors: 8
Affiliation:
[1] Univ Campinas UNICAMP, Fac Med Sci, Dept Pathol, Campinas, SP - Brazil
[2] Univ Campinas UNICAMP, Piracicaba Dent Sch, Dept Oral Pathol, Piracicaba - Brazil
[3] Peruvian Univ Cayetano Heredia, Dept Oral Pathol Med & Surg, Lima - Peru
[4] AC Camargo Hosp, Dept Pathol, Sao Paulo - Brazil
[5] AC Camargo Hosp, Dept Head & Neck & Otorhinolaryngol, Sao Paulo - Brazil
Total Affiliations: 5
Document type: Journal article
Source: Histopathology; v. 63, n. 4, p. 558-567, OCT 2013.
Web of Science Citations: 29
Abstract

AimsMammary analogue secretory carcinoma (MASC) of salivary glands shows morphological similarities to milk-secreting mammary epithelial cells. The aim of this study was to analyse the immunohistochemical expression of adipophilin (a component of milk lipid globule membranes) and of proteins related to secretory mechanisms (STAT5a and mammaglobin) in MASC and other salivary tumours. Methods and resultsTen cases of MASC (all with ETV6 translocation) and 83 other salivary carcinomas were studied. In all MASC cases, adipophilin stained numerous large lipid droplets. These droplets were minute in other salivary carcinomas, except for sebaceous carcinoma. Overexpression of STAT5a was detected in all MASC cases, but only occasionally in other carcinomas. Mammaglobin expression occurred frequently in MASC (70% of cases), whereas, in other carcinomas, it was uncommon and limited. Only MASC showed cytoplasmic reactivity for p63, particularly in papillary-cystic areas. Positivity for S100, vimentin and high molecular weight keratin was observed in 100% of MASC cases. ConclusionsMASC is a lipid-rich tumour containing large lipid droplets covered by adipophilin. This finding can be included among its defining immunohistochemical features, and possibly represents lactation-like secretory differentiation. Strong expression of STAT5a and cytoplasmic p63 in MASC reinforces this hypothesis. (AU)

FAPESP's process: 12/18086-6 - Intracytoplasmic lipid droplets in salivary gland tumors: immunohistochemical study
Grantee:Albina Messias de Almeida Milani Altemani
Support type: Regular Research Grants
FAPESP's process: 11/23204-5 - Genomic profile study of carcinoma ex-pleomorphic adenoma by array-comparative genomic hybridization
Grantee:Albina Messias de Almeida Milani Altemani
Support type: Regular Research Grants
FAPESP's process: 11/23366-5 - Genomic profile study of carcinoma ex-pleomorphic adenoma by array-comparative genomic hybridization
Grantee:Fernanda Viviane Mariano Brum Corrêa
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 12/18104-4 - Intracytoplasmic lipid droplets in salivary gland tumors. Immunohistochemical study
Grantee:Harim Tavares dos Santos
Support type: Scholarships in Brazil - Master