| Texto completo | |
| Autor(es): |
Boas Nogueira, Andressa Vilas
[1]
;
Chaves de Souza, Joao Antonio
[1]
;
Kim, Yeon Jung
[2]
;
de Sousa-Neto, Manoel Damiao
[3]
;
Cirelli, Carolina Chan
;
Cirelli, Joni Augusto
[1]
Número total de Autores: 6
|
| Afiliação do(s) autor(es): | [1] Univ Estadual Paulista UNESP, Sch Dent Araraquara, Dept Diag & Surg, Araraquara - Brazil
[2] Univ Santo Amaro, Dept Implantol, Santo Amaro - Brazil
[3] Univ Sao Paulo, Dept Restorat Dent, BR-14049 Ribeirao Preto - Brazil
Número total de Afiliações: 3
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Journal of Periodontology; v. 84, n. 9, p. 1319-1326, SEP 2013. |
| Citações Web of Science: | 17 |
| Resumo | |
Background: The present study aims to evaluate the effects of orthodontic movement (OM) on the periodontal tissues of rats with ligature-induced periodontal disease. Methods: Eighty-eight rats were divided into four groups: 1) negative control (sham operated); 2) periodontal disease; 3) OM; and 4) periodontal disease followed by OM (OMP). Rats were sacrificed 3 hours or 1, 3, or 7 days after OM commencement. Bone volume fraction (BVF) and bone mineral density (BMD) were assessed in hemimaxillae by microcomputed tomography analysis. Expression of the proinflammatory cytokines interleukin (IL)-1 beta and tumor necrosis factor (TNF)-alpha were evaluated in gingival samples by quantitative polymerase chain reaction and enzyme-linked immunosorbent assay, and in the furcation region by immunohistochemistry analysis (IHC). Results: The OMP group had lower BVF and BMD levels compared to the other groups at day 7 (P <0.05). Maximum messenger ribonucleic acid expression of both cytokines was observed in the OMP group at day 1 (P <0.05). In the same period, all proteins were expressed in high levels for all test groups compared to the control group. The number of cells positive for IL-1 beta and TNF-alpha by IHC was highest in the OMP group at day 1, with progressive reduction thereafter. Conclusion: The results suggest that OM acts synergistically with periodontal disease in periodontal breakdown through upregulation of proinflammatory cytokines. (AU) | |
| Processo FAPESP: | 10/07771-4 - Efeito da movimentação ortodôntica na progressão da doença periodontal. Estudos in vivo e in vitro. |
| Beneficiário: | Andressa Vilas Boas Nogueira |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado |
| Processo FAPESP: | 08/02506-0 - Efeitos da movimentação ortodôntica na expressão de mediadores inflamatórios nos tecidos periodontais de ratos em condições de saúde ou doença periodontal induzida. |
| Beneficiário: | Andressa Vilas Boas Nogueira |
| Modalidade de apoio: | Bolsas no Brasil - Mestrado |
| Processo FAPESP: | 08/06328-0 - Efeitos da movimentação ortodôntica na expressão de mediadores inflamatórios nos tecidos periodontais de ratos em condições de saúde ou doença periodontal induzida. |
| Beneficiário: | Joni Augusto Cirelli |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |