Systemic Chemotherapy Interferes in Homocysteine Metabolism in Breast Cancer Patients

Autor(es):Mostrar menos -

Yamashita, Eliana K. ^[1] ; Teixeira, Bianca M. ^[1] ; Yoshihara, Renata N. ^[1] ; Kuniyoshi, Renata K. ^{[2, 1]} ; Alves, Beatriz C. A. ^[1] ; Gehrke, Flavia S. ^[1] ; Vilas-Boas, Viviane A. ^[1] ; Correia, Joao A. ^[1] ; Azzalis, Ligia A. ^[3] ; Junqueira, Virginia B. C. ^[3] ; Pereira, Edimar Cristiano ^[3] ; Fonseca, Fernando L. A. ^{[3, 1]}

Afiliação do(s) autor(es)

^[1] ABC, Sch Med, Dept Hematol & Oncol, Santo Andre, SP - Brazil

^[2] Univ Sao Paulo, Sch Med, Sao Paulo - Brazil

^[3] Univ Fed Sao Paulo, Dept Biol Sci, BR-09972270 Diadema, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF CLINICAL LABORATORY ANALYSIS; v. 28, n. 2, p. 157-162, MAR 2014.
• Citações Web of Science: 4

Resumo

Background Hyperhomocysteinemia in breast cancer (BC) patients can be a risk factor for thromboembolic events. This study aimed to evaluate homocysteine and its cofators (folic acid and vitamin B12) concentrations and platelet count at diagnosis of BC, 3 and 6 months after the beginning of chemotherapy treatment and to correlate them with clinical data. Methods Thirty-five BC patients were included; blood samples were obtained by venipuncture. Plasmatic Hcy and cofactors concentrations were measured by competitive chemiluminescent enzyme immunoassay method. Platelet count was done using an automated analyzer. Statistical analysis was performed using the software SPSS. Results During chemotherapy, homocysteine (P = 0.032) and vitamin B12 (P < 0.001) concentrations increased, while folate and platelets decreased (P < 0.001). Among the clinical data, the menopausal status showed significant positive correlation (P = 0.022) with homocysteine concentration increase. Conclusions Evaluation of homocysteine concentrations during chemotherapy is extremely important because their levels increase during chemotherapy treatment, thus increasing the risk of thromboembolism development. (AU)

• Processo FAPESP: 09/54342-4 - RELACAO DAS CONCENTRACOES DE HOMOCISTEINA COM A EXPRESSAO DE CK-19 E c-erb-B2 EM PACIENTES COM CANCER DE MAMA DURANTE O TRATAMENTO QUIMIOTERAPICO.
• Beneficiário: Bianca Marinelli Teixeira
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica
• Processo FAPESP: 09/54343-0 - RELACAO DAS CONCENTRACOES DE HOMOCISTEINA COM A EXPRESSAO DE CK-19 E c-erb-B2 EM PACIENTES COM CANCER DE MAMA DURANTE O TRATAMENTO QUIMIOTERAPICO.
• Beneficiário: Renata Nunes Yoshihara
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica