Square-wave adsorptive stripping voltammetric determination of nanomolar levels of bezafibrate using a glassy carbon electrode modified with multi-walled carbon nanotubes within a dihexadecyl hydrogen phosphate film

Autor(es)

Ardila, Jorge Armando ^[1] ; Oliveira, Geiser Gabriel ^[2] ; Medeiros, Roberta Antigo ^[3] ; Fatibello-Filho, Orlando ^{[1, 4]}

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Paulo, Dept Quim, BR-13560970 Sao Carlos, SP - Brazil

^[2] Univ Sao Paulo, Inst Quim Sao Carlos, BR-13560970 Sao Carlos, SP - Brazil

^[3] Univ Oeste Parana, Ctr Engn & Ciencias Exatas, BR-85903000 Toledo, PR - Brazil

^[4] INCT Bioanalit, BR-13083970 Campinas, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: ANALYST; v. 139, n. 7, p. 1762-1768, 2014.
• Citações Web of Science: 14

Resumo

A highly sensitive method for bezafibrate determination using a glassy carbon electrode (GCE) modified with multi-walled carbon nanotubes within a dihexadecyl hydrogen phosphate film based on square-wave adsorptive stripping voltammetry (SWAdSV) is proposed. The electrochemical behaviour of bezafibrate has been studied by cyclic voltammetry, showing an irreversible anodic peak at a potential of 1.09 V in 0.1 mol L-1 phosphate buffer solution (pH 2.0). A study of the scan rate showed that the oxidation of bezafibrate is an adsorptive-controlled process, involving the transfer of two electrons and two protons per molecule. The analytical curve was linear over a bezafibrate concentration range from 50 to 910 nmol L-1, with a detection limit of 16 nmol L-1. This analytical method was successfully applied for benzafibrate determination in pharmaceutical formulations, with results showing good agreement with those obtained using a comparative spectrophotometric method, and has the potential for field application. (AU)

• Processo FAPESP: 11/00601-9 - Aplicação de eletrodos de diamante dopado com boro e de nitreto de carbono amorfo para a determinação simultânea de fármacos de diferentes grupos terapêuticos em formulações farmacêuticas e em urina
• Beneficiário: Roberta Antigo Medeiros
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado