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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Square-wave adsorptive stripping voltammetric determination of nanomolar levels of bezafibrate using a glassy carbon electrode modified with multi-walled carbon nanotubes within a dihexadecyl hydrogen phosphate film

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Author(s):
Ardila, Jorge Armando [1] ; Oliveira, Geiser Gabriel [2] ; Medeiros, Roberta Antigo [3] ; Fatibello-Filho, Orlando [1, 4]
Total Authors: 4
Affiliation:
[1] Univ Fed Sao Paulo, Dept Quim, BR-13560970 Sao Carlos, SP - Brazil
[2] Univ Sao Paulo, Inst Quim Sao Carlos, BR-13560970 Sao Carlos, SP - Brazil
[3] Univ Oeste Parana, Ctr Engn & Ciencias Exatas, BR-85903000 Toledo, PR - Brazil
[4] INCT Bioanalit, BR-13083970 Campinas, SP - Brazil
Total Affiliations: 4
Document type: Journal article
Source: ANALYST; v. 139, n. 7, p. 1762-1768, 2014.
Web of Science Citations: 14
Abstract

A highly sensitive method for bezafibrate determination using a glassy carbon electrode (GCE) modified with multi-walled carbon nanotubes within a dihexadecyl hydrogen phosphate film based on square-wave adsorptive stripping voltammetry (SWAdSV) is proposed. The electrochemical behaviour of bezafibrate has been studied by cyclic voltammetry, showing an irreversible anodic peak at a potential of 1.09 V in 0.1 mol L-1 phosphate buffer solution (pH 2.0). A study of the scan rate showed that the oxidation of bezafibrate is an adsorptive-controlled process, involving the transfer of two electrons and two protons per molecule. The analytical curve was linear over a bezafibrate concentration range from 50 to 910 nmol L-1, with a detection limit of 16 nmol L-1. This analytical method was successfully applied for benzafibrate determination in pharmaceutical formulations, with results showing good agreement with those obtained using a comparative spectrophotometric method, and has the potential for field application. (AU)

FAPESP's process: 11/00601-9 - Application of boron-doped diamond and amorphous carbon nitride electrodes for the simultaneous determination of drugs of different therapeutic groups in pharmaceutical formulations and urine samples
Grantee:Roberta Antigo Medeiros
Support Opportunities: Scholarships in Brazil - Post-Doctoral