SENSORS DEVELOPMENT BASED ON POLYMERIC FILMS AND NANOMATERIALS FOR SEVERAL ANALYTICAL APPLICATIONS

• Grant number: 13/16770-0
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• Effective date (Start): November 01, 2013
• Effective date (End): October 31, 2015
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Analytical Chemistry
• Principal Investigator: Orlando Fatibello Filho
• Grantee: Fernando Campanhã Vicentini
• Host Institution: Centro de Ciências Exatas e de Tecnologia (CCET). Universidade Federal de São Carlos (UFSCAR). São Carlos , SP, Brazil

Abstract

New architectures for sensors and/or biosensors will be developed in this project. For this, glassy carbon electrodes and/or pyrolytic graphite electrodes will be modified with nanomaterials (carbon black, carbon nanotubes or metal nanoparticles) within chitosan, polyelectrolytes as polyallylamine hydrochloride or surfactants as dihexadecyl hydrogen phosphate films. For biosensors, enzymes of interest will be immobilized with glyoxal, glutaraldehyde, 1-ethyl-3-(3-dimethylaminopropyl) and carbodiimide/N-hydroxysuccinimide depending on the composition of the sensor base. The electrochemical characteristics of sensors/biosensors will be evaluated by electrochemical techniques such as: cyclic voltammetry, impedance spectroscopy and chronoamperometry. With these modifications, the objective is improve significantly the detection properties of these electrochemical devices, improving the electrochemical response in terms of the decrease in overpotential of the electrode, which is often high, reduce the interference of electroactive species, and may thus increase the selectivity. Furthermore, it is also expected to obtain an increase in the current magnitude (increase of the analytic signal) and/or increased sensitivity (slope of the calibration curve).The use of electrochemical probes such as potassium hexacyanoferrate(III) and/or hexaammineruthenium(III) will be employed to evaluate the electrochemical properties of electrodes modified with nanomaterials , being active area, the coverage area and heterogeneous electron transfer constant determined and compared. Initially will be evaluated the linear range of response, detection and quantification limits, sensitivity, potential interferences and lifetime of the electrodes. The electrodes with improved analytical performance will be applied in the determination of analytes of environmental, biological and pharmaceutical interest.

Scientific publications

(13)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DEROCO, PATRICIA BATISTA; VICENTINI, FERNANDO CAMPANHA; FATIBELLO-FILHO, ORLANDO. An Electrochemical Sensor for the Simultaneous Determination of Paracetamol and Codeine Using a Glassy Carbon Electrode Modified with Nickel Oxide Nanoparticles and Carbon Black. Electroanalysis, v. 27, n. 9, SI, p. 2214-2220, SEP 2015. (14/07919-2, 13/16770-0)

SIMIONI, NATALIA BORTOLUCCI; OLIVEIRA, GEISER GABRIEL; VICENTINI, FERNANDO CAMPANHA; LANZA, MARCOS R. V.; JANEGITZ, BRUNO C.; FATIBELLO-FILHO, ORLANDO. Nanodiamonds stabilized in dihexadecyl phosphate film for electrochemical study and quantification of codeine in biological and pharmaceutical samples. DIAMOND AND RELATED MATERIALS, v. 74, p. 191-196, APR 2017. (15/19099-2, 13/16770-0)

SILVA, TIAGO ALMEIDA; ZANIN, HUDSON; VICENTINI, FERNANDO CAMPANHA; CORAT, EVALDO JOSE; FATIBELLO-FILHO, ORLANDO. Electrochemical determination of rosuvastatin calcium in pharmaceutical and human body fluid samples using a composite of vertically aligned carbon nanotubes and graphene oxide as the electrode material. SENSORS AND ACTUATORS B-CHEMICAL, v. 218, p. 51-59, OCT 31 2015. (14/02163-7, 14/21587-2, 13/16770-0)

VICENTINI, FERNANDO CAMPANHA; GARCIA, LIVIA L. C.; FIGUEIREDO-FILHO, LUIZ C. S.; JANEGITZ, BRUNO C.; FATIBELLO-FILHO, ORLANDO. A biosensor based on gold nanoparticles, dihexadecylphosphate, and tyrosinase for the determination of catechol in natural water. Enzyme and Microbial Technology, v. 84, p. 17-23, MAR 2016. (14/04284-6, 13/16770-0)

SANTOS, ANDERSON M.; VICENTINI, FERNANDO C.; FIGUEIREDO-FILHO, LUIZ C. S.; DEROCO, PATRICIA B.; FATIBELLO-FILHO, ORLANDO. Flow injection simultaneous determination of acetaminophen and tramadol in pharmaceutical and biological samples using multiple pulse amperometric detection with a boron-doped diamond electrode. DIAMOND AND RELATED MATERIALS, v. 60, p. 1-8, NOV 2015. (14/07919-2, 14/04284-6, 13/16770-0)

VICENTINI, FERNANDO CAMPANHA; RAVANINI, AMANDA E.; FIGUEIREDO-FILHO, LUIZ C. S.; INIESTA, JESUS; BANKS, CRAIG E.; FATIBELLO-FILHO, ORLANDO. Imparting improvements in electrochemical sensors: evaluation of different carbon blacks that give rise to significant improvement in the performance of electroanalytical sensing platforms. Electrochimica Acta, v. 157, p. 125-133, MAR 1 2015. (10/20754-1, 14/04284-6, 13/16770-0)

VICENTINI, FERNANDO CAMPANHA; RAVANINI, AMANDA ELISA; SILVA, TIAGO ALMEIDA; JANEGITZ, BRUNO C.; ZUCOLOTTO, VALTENCIR; FATIBELLO-FILHO, ORLANDO. A novel architecture based upon multi-walled carbon nanotubes and ionic liquid to improve the electroanalytical detection of ciprofibrate. ANALYST, v. 139, n. 16, p. 3961-3967, AUG 21 2014. (12/02877-4, 13/16770-0)

FIGUEIREDO-FILHO, LUIZ C. S.; SILVA, TIAGO A.; VICENTINI, FERNANDO C.; FATIBELLO-FILHO, ORLANDO. Simultaneous voltammetric determination of dopamine and epinephrine in human body fluid samples using a glassy carbon electrode modified with nickel oxide nanoparticles and carbon nanotubes within a dihexadecylphosphate film. ANALYST, v. 139, n. 11, p. 2842-2849, 2014. (10/20754-1, 13/16770-0)

VICENTINI, FERNANDO CAMPANHA; RAYMUNDO-PEREIRA, PAULO A.; JANEGITZ, BRUNO C.; MACHADO, SERGIO A. S.; FATIBELLO-FILHO, ORLANDO. Nanostructured carbon black for simultaneous sensing in biological fluids. SENSORS AND ACTUATORS B-CHEMICAL, v. 227, p. 610-618, MAY 2016. (12/17689-9, 15/19099-2, 12/02877-4, 13/16770-0)

MARRETO, PAOLA D.; TRENCH, ALINE B.; VICENTINI, FERNANDO C.; FIGUEIREDO-FILHO, LUIZ C. S.; MEDEIROS, ROBERTA A.; PEREIRA, ERNESTO. C.; FATIBELLO-FILHO, ORLANDO. Square-Wave Voltammetric Determination of Nanomolar Levels of Linuron in Environmental Water Samples Using a Glassy Carbon Electrode Modified with Platinum Nanoparticles within a Dihexadecyl Phosphate Film. AUSTRALIAN JOURNAL OF CHEMISTRY, v. 68, n. 5, p. 800-805, 2015. (10/20754-1, 11/00601-9, 13/16770-0)

DEROCO, PATRICIA BATISTA; VICENTINI, FERNANDO CAMPANHA; FATIBELLO-FILHO, ORLANDO. An Electrochemical Sensor for the Simultaneous Determination of Paracetamol and Codeine Using a Glassy Carbon Electrode Modified with Nickel Oxide Nanoparticles and Carbon Black. Electroanalysis, v. 27, n. 9, p. 7-pg., 2015-09-01. (13/16770-0, 14/07919-2)

SANTOS, ANDERSON M.; VICENTINI, FERNANDO C.; DEROCO, PATRICIA B.; ROCHA-FILHO, ROMEU C.; FATIBELLO-FILHO, ORLANDO. Square-Wave Voltammetric Determination of Paracetamol and Codeine in Pharmaceutical and Human Body Fluid Samples Using a Cathodically Pretreated Boron-Doped Diamond Electrode. Journal of the Brazilian Chemical Society, v. 26, n. 10, p. 2159-2168, OCT 2015. (14/07919-2, 13/16770-0)

JANEGITZ, BRUNO C.; FIGUEIREDO-FILHO, LUIZ C. S.; VICENTINI, FERNANDO CAMPANHA; RIBEIRO, MARIA FERNANDA M.; SUAREZ, WILLIAN T.; FATIBELLO-FILHO, ORLANDO; METTERS, JONATHAN P.; BANKS, CRAIG E.. Development of a carbon nanotube paste electrode modified with zinc phosphate for captopril determination in pharmaceutical and biological samples. ANALYTICAL METHODS, v. 6, n. 5, p. 1324-1329, 2014. (10/20754-1, 08/09893-0, 12/02877-4, 13/16770-0)