Development of a carbon nanotube paste electrode modified with zinc phosphate for captopril determination in pharmaceutical and biological samples

Author(s)

Janegitz, Bruno C. ^{[1, 2]} ; Figueiredo-Filho, Luiz C. S. ^[1] ; Vicentini, Fernando Campanha ^[1] ; Ribeiro, Maria Fernanda M. ^[1] ; Suarez, Willian T. ^[3] ; Fatibello-Filho, Orlando ^[1] ; Metters, Jonathan P. ^[4] ; Banks, Craig E. ^[4]

Affiliation

^[1] Univ Fed Sao Carlos, Dept Quim, Ctr Ciencias Exatas & Tecnol, BR-13560970 Sao Carlos, SP - Brazil

^[2] Univ Sao Paulo, Inst Fis Sao Carlos, Grp Nanomed & Nanotoxicidade, BR-13566590 Sao Carlos, SP - Brazil

^[3] Univ Fed Vicosa, Dept Quim, BR-36570000 Vicosa, MG - Brazil

^[4] Manchester Metropolitan Univ, Div Chem & Environm Sci, Sch Chem & Environm, Fac Sci & Engn, Manchester M1 5GD, Lancs - England

• Document type: Journal article
• Source: ANALYTICAL METHODS; v. 6, n. 5, p. 1324-1329, 2014.
• Web of Science Citations: 8

Abstract

We report a novel electrode composite comprising zinc phosphate within a multiwalled carbon nanotube paste electrode matrix which is applied for the detection of trace amounts of captopril (CAP) via square-wave adsorptive anodic stripping voltammetry (SWAdASV); to the best of our knowledge this is the first report on such a composite electrode. Under optimum experimental conditions, the peak current of CAP was found to be linear over the concentration range from 3.7 to 67 mu mol L-1 with a limit of detection of 0.1 mu mol L-1. The proposed method was applied for the successful determination of CAP in commercial tablet excipients and biological samples using the electroanalytical protocol evaluated against the laboratory standard iodometric procedure. Excellent comparability between the two is found suggesting that the former can replace the latter within laboratory settings or can be applied to in-the-field applications. (AU)

• FAPESP's process: 10/20754-1 - Development of electrochemical sensors based on nanomaterials for the determination of interest pharmaceutical and environmental species
• Grantee: Luiz Carlos Soares de Figueiredo Filho
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 08/09893-0 - DEVELOPMENT OF BIOSENSORS USING CARBON NANOTUBE AND NANOPARTICLES
• Grantee: Bruno Campos Janegitz
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 12/02877-4 - Development of New Biosensors Using Active Nanoesctrutured Materials
• Grantee: Bruno Campos Janegitz
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 13/16770-0 - SENSORS DEVELOPMENT BASED ON POLYMERIC FILMS AND NANOMATERIALS FOR SEVERAL ANALYTICAL APPLICATIONS
• Grantee: Fernando Campanhã Vicentini
• Support Opportunities: Scholarships in Brazil - Post-Doctoral