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Evaluation and analytical application of boron doped diamond porous electrodes for voltammetric determination of biomolecules, ascorbic acid, uric acid, dopamine and adrenaline in biological fluids and/or pharmaceutical formulations

Grant number: 14/03019-7
Support type:Scholarships in Brazil - Post-Doctorate
Effective date (Start): August 01, 2014
Effective date (End): June 30, 2017
Field of knowledge:Physical Sciences and Mathematics - Chemistry
Cooperation agreement: Coordination of Improvement of Higher Education Personnel (CAPES)
Principal Investigator:Orlando Fatibello Filho
Grantee:Bruna Cláudia Lourenção
Home Institution: Centro de Ciências Exatas e de Tecnologia (CCET). Universidade Federal de São Carlos (UFSCAR). São Carlos , SP, Brazil

Abstract

In recent years new carbon materials have been used as working electrode and have drawn attention due to the excellent results obtained.The films of porous boron doped diamond (BDD) are a new class of hybrid materials carbon and have potential relevance for applications in electroanalysis due to their interesting electrochemical properties. This hybrid material combines excellent conductivity and electron transport of the electrodes of carbon nanotubes (CNTs) with rugged surface of BDD films with high content of carbon sp3.The use of electroanalytical techniques for the determination of organic and inorganic compounds has grown significantly since it takes, accurate sensitive, low cost and require short analysis times and in many cases the simple preparation of samples.Thus, the aim of this study is to evaluate the analytical potential of a porous BDD electrode performing fundamental studies related to the electrochemical behavior of this, comparing it with conventional electrodes (BDD flat) and vertically aligned carbon nanotubes (VACNTs). Additionally, after evaluate of the use of the electrode for the determination of some important biomolecules whose electrochemical behavior is known, its can still be applied in the determination of compounds of interest (analytes) in environmental, pharmaceutical or food with the evaluation of analytical conditions for the development of a good procedure.Moreover, if necessary, these porous BDD electrodes can be modified with surface treatments as well as planar BDD to improve their analytical performance (analytical method) such as selectivity, sensitivity, precision, accuracy and reproducibility. (AU)

Scientific publications (7)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
LOURENCAO, BRUNA CLAUDIA; SILVA, TIAGO ALMEIDA; SANTOS, MAIARA DA SILVA; FERREIRA, ANTONIO GILBERTO; FATIBELLO-FILHO, ORLANDO. Sensitive voltammetric determination of hydroxyzine and its main metabolite cetirizine and identification of oxidation products by nuclear magnetic resonance spectroscopy. JOURNAL OF ELECTROANALYTICAL CHEMISTRY, v. 807, p. 187-195, DEC 15 2017. Web of Science Citations: 3.
BROCENSCHI, RICARDO F.; SILVA, TIAGO A.; LOURENCAO, BRUNA C.; FATIBELLO-FILHO, ORLANDO; ROCHA-FILHO, ROMEU C. Use of a boron-doped diamond electrode to assess the electrochemical response of the naphthol isomers and to attain their truly simultaneous electroanalytical determination. Electrochimica Acta, v. 243, p. 374-381, JUL 20 2017. Web of Science Citations: 12.
DEROCO, PATRICIA BATISTA; LOURENCAO, BRUNA CLAUDIA; FATIBELLO-FILHO, ORLANDO. The use of modified electrode with carbon black as sensor to the electrochemical studies and voltammetric determination of pesticide mesotrione. Microchemical Journal, v. 133, p. 188-194, JUL 2017. Web of Science Citations: 17.
LOURENCAO, BRUNA C.; PINHEIRO, ROMARIO A.; SILVA, TIAGO A.; CORAT, EVALDO J.; FATIBELLO-FILHO, ORLANDO. Porous boron-doped diamond/CNT electrode as electrochemical sensor for flow-injection analysis applications. DIAMOND AND RELATED MATERIALS, v. 74, p. 182-190, APR 2017. Web of Science Citations: 8.
LOURENCAO, BRUNA C.; MEDEIROS, ROBERTA A.; THOMASI, SERGIO SCHERRER; FERREIRA, ANTONIO GILBERTO; ROCHA-FILHO, ROMEU C.; FATIBELLO-FILHO, ORLANDO. Amperometric flow-injection determination of the anthelmintic drugs ivermectin and levamisole using electrochemically pretreated boron-doped diamond electrodes. SENSORS AND ACTUATORS B-CHEMICAL, v. 222, p. 181-189, JAN 2016. Web of Science Citations: 16.
LOURENCAO, BRUNA C.; MEDEIROS, ROBERTA A.; FATIBELLO-FILHO, ORLANDO. Simultaneous determination of antihypertensive drugs by flow injection analysis using multiple pulse amperometric detection with a cathodically pretreated boron-doped diamond electrode. Journal of Electroanalytical Chemistry, v. 754, p. 154-159, OCT 1 2015. Web of Science Citations: 15.
LAÍS PEREIRA SILVA; BRUNA C. LOURENCAO; ORLANDO FATIBELLO-FILHO. DETERMINAÇÃO VOLTAMÉTRICA SIMULTÂNEA DE BESILATO DE ANLODIPINO E HIDROCLOROTIAZIDA EM AMOSTRAS DE URINA SINTÉTICA UTILIZANDO UM ELETRODO DE DIAMANTE DOPADO COM BORO. Química Nova, v. 38, n. 6, p. 801-806, Jul. 2015.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.