High resolution magic angle spinning NMR as a tool for unveiling the molecular enantiorecognition of omeprazole by amylose-based chiral phase

Autor(es)

Barreiro, Juliana Cristina ^[1] ; Lourenco, Tiago de Campos ^[1] ; Silva, Lorena Mara A. ^[1] ; Venancio, Tiago ^[1] ; Cass, Quezia Bezerra ^[1]

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Carlos, Dept Chem, BR-13560 Sao Carlos, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: ANALYST; v. 139, n. 6, p. 1350-1354, 2014.
• Citações Web of Science: 8

Resumo

Polysaccharide-based chiral stationary phases (CSP) demonstrate great versatility and higher chiral selectivity for a variety of chiral compounds in multimodal elution modes (normal, reverse and polar organic). The main role of CSP phenyl carbamate based derivatives as chiral selectors is the formation of diastereoisomeric complexes by means of pi-pi interaction, dipole-dipole, hydrogen bonding and/or inclusion complex mechanisms. Nevertheless, the mechanism behind their enantioselectivity requires clarification. High resolution magic angle spinning nuclear magnetic resonance spectroscopy (H-1 HR/MAS NMR) has provided key information on the recognition process at the binding sites of the CSP surface. Herein we report the results obtained using omeprazole as a probe for these investigations. (AU)

• Processo FAPESP: 08/05778-1 - Fármacos quirais em águas residuais: quantificação e estudos de mecanismos de separação enantiosseletiva
• Beneficiário: Juliana Cristina Barreiro
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado