pH in exhaled breath condensate and nasal lavage as a biomarker of air pollution-related inflammation in street traffic-controllers and office-workers

Autor(es):Mostrar menos -

de Lima, Thamires Marques ^[1] ; Kazama, Cristiane Mayumi ^{[1, 2]} ; Koczulla, Andreas Rembert ^[3] ; Hiemstra, Pieter S. ^[4] ; Macchione, Mariangela ^[1] ; Godoy Fernandes, Ana Luisa ^[5] ; Santos, Ubiratan de Paula ^[6] ; Bueno-Garcia, Maria Lucia ^[7] ; Zanetta, Dirce Maria ^[8] ; Saldiva de Andre, Carmen Diva ^[9] ; Nascimento Saldiva, Paulo Hilario ^[1] ; Nakagawa, Naomi Kondo ^{[1, 2]}

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Fac Med, Dept Pathol, Sao Paulo - Brazil

^[2] Univ Sao Paulo, Fac Med, Dept Physiotherapy Commun Sci & Disorders & Occup, Sao Paulo - Brazil

^[3] Univ Marburg, Dept Pulmonol, Marburg - Germany

^[4] Leiden Univ, Med Ctr, Dept Pulmonol, Leiden - Netherlands

^[5] Univ Fed Sao Paulo, Sch Med, Dept Pneumol, Sao Paulo - Brazil

^[6] Univ Sao Paulo, Fac Med, Inst Coracao INCOR, Div Pneumol, Sao Paulo - Brazil

^[7] Univ Sao Paulo, Fac Med, Dept Internal Med, Sao Paulo - Brazil

^[8] Univ Sao Paulo, Publ Hlth Fac, Dept Epidemiol, Sao Paulo - Brazil

^[9] Univ Sao Paulo, Inst Math & Stat, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Clinics; v. 68, n. 12, p. 1488-1494, 2013.
• Citações Web of Science: 8

Resumo

OBJECTIVE: To utilize low-cost and simple methods to assess airway and lung inflammation biomarkers related to air pollution. METHODS: A total of 87 male, non-smoking, healthy subjects working as street traffic-controllers or office-workers were examined to determine carbon monoxide in exhaled breath and to measure the pH in nasal lavage fluid and exhaled breath condensate. Air pollution exposure was measured by particulate matter concentration, and data were obtained from fixed monitoring stations (8-h work intervals per day, during the 5 consecutive days prior to the study). RESULTS: Exhaled carbon monoxide was two-fold greater in traffic-controllers than in office-workers. The mean pH values were 8.12 in exhaled breath condensate and 7.99 in nasal lavage fluid in office-workers; these values were lower in traffic-controllers (7.80 and 7.30, respectively). Both groups presented similar cytokines concentrations in both substrates, however, IL-1β and IL-8 were elevated in nasal lavage fluid compared with exhaled breath condensate. The particulate matter concentration was greater at the workplace of traffic-controllers compared with that of office-workers. CONCLUSION: The pH values of nasal lavage fluid and exhaled breath condensate are important, robust, easy to measure and reproducible biomarkers that can be used to monitor occupational exposure to air pollution. Additionally, traffic-controllers are at an increased risk of airway and lung inflammation during their occupational activities compared with office-workers. (AU)

• Processo FAPESP: 09/50056-7 - Poluicao atmosferica e marcadores inflamatorios em lavado nasal e condensado do ar exalado em controladores de trafego da cidade de sao paulo
• Beneficiário: Thamires Marques de Lima
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica
• Processo FAPESP: 07/51605-9 - Marcadores de defesa pulmonar e microcirculação
• Beneficiário: Naomi Kondo Nakagawa
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores