Effect of fluoride gels supplemented with sodium trimetaphosphate in reducing demineralization

Autor(es)

Danelon, Marcelle ^[1] ; Takeshita, Eliana Mitsue ^[1] ; Peixoto, Ligia Carla ^[1] ; Sassaki, Kikue Takebayashi ^[2] ; Botazzo Delbem, Alberto Carlos ^[1]

Afiliação do(s) autor(es)

^[1] UNESP Univ Estadual Paulista, Aracatuba Sch Dent, Dept Pediat Dent & Publ Hlth, BR-16015050 Aracatuba, SP - Brazil

^[2] UNESP Univ Estadual Paulista, Dept Basic Sci, Aracatuba Sch Dent, BR-16015050 Aracatuba, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: CLINICAL ORAL INVESTIGATIONS; v. 18, n. 4, p. 1119-1127, MAY 2014.
• Citações Web of Science: 17

Resumo

The objective of this study was to evaluate the in vitro effect of low-fluoride (F) gels supplemented with sodium trimetaphosphate (TMP) on enamel demineralization. Bovine enamel blocks (n = 160) were selected based on surface hardness (SH) and divided into eight treatment groups (n = 20 per group): no F or TMP (placebo), 3 % TMP (3 %TMP), 5 % TMP (5 %TMP), 4,500 mu g F/g (4,500), 4,500 mu g F/g + 3 % TMP (4,500 3 %TMP), 4,500 mu g F/g + 5 % TMP (4,500 5 %TMP), 9,000 mu g F/g (9,000), and 12,300 mu g F/g (acid gel). Blocks were subjected to demineralization/remineralization cycling for 5 days. Subsequently, surface hardness (SH1) and integrated loss of subsurface hardness (Delta KHN) were assessed, and the concentrations of loosely bound (CaF2-like) and firmly bound (FA-like) formed and retained F were determined. The 4,500 5 %TMP and acid gel groups showed similar results and had the lowest mineral loss (SH1 and a dagger KHN). The acid gel group had the highest concentration of CaF2-like F, but the formation and retention of FA-like F was greater in the 4,500 5 %TMP group than in the acid gel group (p < 0.05). It is possible to inhibit enamel demineralization with low-F gels supplementing these gels with 5 % TMP. The low-F gel containing TMP can be regarded as a safer alternative for clinical use from a toxicological point of view since it contains half of the amount of a conventional formulation while promoting similar anticaries effect. (AU)

• Processo FAPESP: 08/08913-7 - Desenvolvimento de gel tópico com reduzida concentração de fluoreto: capacidade de inibir a desmineralização e favorecer a remineralização do esmalte dentário
• Beneficiário: Marcelle Danelon
• Modalidade de apoio: Bolsas no Brasil - Mestrado