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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Effect of fluoride gels supplemented with sodium trimetaphosphate in reducing demineralization

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Author(s):
Danelon, Marcelle [1] ; Takeshita, Eliana Mitsue [1] ; Peixoto, Ligia Carla [1] ; Sassaki, Kikue Takebayashi [2] ; Botazzo Delbem, Alberto Carlos [1]
Total Authors: 5
Affiliation:
[1] UNESP Univ Estadual Paulista, Aracatuba Sch Dent, Dept Pediat Dent & Publ Hlth, BR-16015050 Aracatuba, SP - Brazil
[2] UNESP Univ Estadual Paulista, Dept Basic Sci, Aracatuba Sch Dent, BR-16015050 Aracatuba, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: CLINICAL ORAL INVESTIGATIONS; v. 18, n. 4, p. 1119-1127, MAY 2014.
Web of Science Citations: 17
Abstract

The objective of this study was to evaluate the in vitro effect of low-fluoride (F) gels supplemented with sodium trimetaphosphate (TMP) on enamel demineralization. Bovine enamel blocks (n = 160) were selected based on surface hardness (SH) and divided into eight treatment groups (n = 20 per group): no F or TMP (placebo), 3 % TMP (3 %TMP), 5 % TMP (5 %TMP), 4,500 mu g F/g (4,500), 4,500 mu g F/g + 3 % TMP (4,500 3 %TMP), 4,500 mu g F/g + 5 % TMP (4,500 5 %TMP), 9,000 mu g F/g (9,000), and 12,300 mu g F/g (acid gel). Blocks were subjected to demineralization/remineralization cycling for 5 days. Subsequently, surface hardness (SH1) and integrated loss of subsurface hardness (Delta KHN) were assessed, and the concentrations of loosely bound (CaF2-like) and firmly bound (FA-like) formed and retained F were determined. The 4,500 5 %TMP and acid gel groups showed similar results and had the lowest mineral loss (SH1 and a dagger KHN). The acid gel group had the highest concentration of CaF2-like F, but the formation and retention of FA-like F was greater in the 4,500 5 %TMP group than in the acid gel group (p < 0.05). It is possible to inhibit enamel demineralization with low-F gels supplementing these gels with 5 % TMP. The low-F gel containing TMP can be regarded as a safer alternative for clinical use from a toxicological point of view since it contains half of the amount of a conventional formulation while promoting similar anticaries effect. (AU)

FAPESP's process: 08/08913-7 - Development of topical gel with reduce fluoride concentration: capacity of inhibit the demineralization and improve the remineralization of the dental enamel
Grantee:Marcelle Danelon
Support Opportunities: Scholarships in Brazil - Master