Sustained Clearance of Mansonella ozzardi Infection after Treatment with Ivermectin in the Brazilian Amazon

Autor(es)

Basano, Sergio de Almeida ^{[1, 2]} ; Fontes, Gilberto ^[3] ; Medeiros, Jansen Fernandes ^[4] ; de Almeida Aranha Camargo, Juliana Souza ^[5] ; Souza Vera, Luana Janaina ^[5] ; Parente Araujo, Marcos Paulo ^[5] ; Pires Parente, Maira Santiago ^[5] ; Mattos Ferreira, Ricardo de Godoi ^[4] ; Barreto Crispim, Pedro di Tarique ^[6] ; Aranha Camargo, Luis Marcelo ^{[1, 7]}

Afiliação do(s) autor(es)

^[1] Dept Med, Fac Sao Lucas, Porto Velho, Rondonia - Brazil

^[2] Secretaria Sande Estado Rondonia, Porto Velho, Rondonia - Brazil

^[3] Univ Fed Sao Joao del Rei, Divinopolis, MG - Brazil

^[4] Fiocruz Rondonia, Fundacao Oswaldo Cruz, Porto Velho, Rondonia - Brazil

^[5] Fac Sao Lucas, Porto Velho, Rondonia - Brazil

^[6] Univ Fed Rondonia, Porto Velho, Rondonia - Brazil

^[7] Univ Sao Paulo, Dept Parasitol, Inst Ciencias Biomed 5, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: American Journal of Tropical Medicine and Hygiene; v. 90, n. 6, p. 1170-1175, JUN 2014.
• Citações Web of Science: 14

Resumo

Therapy for mansonelliasis is challenging because there is no standard drug recommended for its treatment. This non-randomized study was conducted to evaluate the effectiveness of a single dose of 0.15 mg/kg of ivermectin to reduce Mansonella ozzardi microfilaraemia in infected persons. A total of 74 patients were studied within the municipality of Labrea, which is located in Amazonas State, Brazil. The patients were treated with ivermectin after detection of the parasite by blood examination. Significant microfilaraemia reduction was observed and its residual effect was maintained for at least 12 months. There was no significant change in the laboratory blood count, hepatic metabolites, and nitrogen-bounding compound excreta dosage values that could compromise the use of this drug, demonstrating that ivermectin has a low toxicity level. (AU)

• Processo FAPESP: 08/10817-6 - Ensaio clínico com o uso de ivermectina para tratamento de infecções por Mansonella ozzardi
• Beneficiário: Luís Marcelo Aranha Camargo
• Modalidade de apoio: Auxílio à Pesquisa - Regular