Using of a graphite-polyurethane composite electrode modified with a Schiff base as a bio-inspired sensor in the dopamine determination

Autor(es)

dos Santos, Sidney X. ^{[1, 2]} ; Cavalheiro, Eder T. G. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Inst Quim Sao Carlos, Dept Quim & Fis Mol, BR-13560970 Sao Carlos, SP - Brazil

^[2] Univ Fed Vicosa, Inst Ciencias Exatas & Tecnol, BR-38810000 Rio Paranaiba, MG - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Journal of the Brazilian Chemical Society; v. 25, n. 6, p. 1071-1077, JUN 2014.
• Citações Web of Science: 8

Resumo

A solid composite electrode based on graphite and polyurethane resin modified with a copper(II) complex of the symmetrical tetradentate Schiff's base type, N, N'-ethylenebis(salicylideneiminato) copper(II) ([Cu(II)Salen]), was evaluated as a bio-inspired sensor using dopamine (DA) as a model analyte. The voltammetric behavior of the modifier [Cu(II)Salen] was investigated at a modified carbon paste electrode and a redox mechanism was proposed. The analytical potentialities of the composite electrode based on graphite and polyurethane resin (GPU) modified with [Cu(II)Salen] (MGPU) were evaluated using DA as probe. MGPU presents best results when compared with GPU without modification, with electrocatalytic effect, indicating that the electrode can be characterized as a bio-inspired sensor. The MGPU electrode was applied in the determination of DA in pharmaceutical formulation using DPV and the results were compared to those obtained with the official method (high performance liquid chromatography, HPLC) as described in US Pharmacopoeia, agreeing within 95% confidence level according to student's t-test. (AU)

• Processo FAPESP: 05/04297-1 - Aplicação de eletrodos compósitos à base de poliuretana/grafite e borracha de silicone/grafite II
• Beneficiário: Éder Tadeu Gomes Cavalheiro
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 11/02705-6 - Desenvolvimento e aplicação de "enzymeless biosensors" via modificação de eletrodos compósitos à base de grafite-poliuretana com complexos metálicos de bases de Schiff.
• Beneficiário: Sidney Xavier dos Santos
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado