Busca avançada
Ano de início
Entree
(Referência obtida automaticamente do SciELO, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Kaposi's sarcoma-associated herpesvirus infection and Kaposi's sarcoma in Brazil

Texto completo
Autor(es):
S. Ramos-da-Silva ; D. Elgui-de-Oliveira ; L. Borges ; C.E. Bacchi
Número total de Autores: 4
Tipo de documento: Artigo Científico
Fonte: Brazilian Journal of Medical and Biological Research; v. 39, n. 5, p. 573-580, Maio 2006.
Resumo

Kaposi's sarcoma (KS) became a critical health issue with the emergence of acquired immunodeficiency syndrome (AIDS) in the 1980s. Four clinical-epidemiological forms of KS have been described: classical KS, endemic KS, iatrogenic KS, and AIDS-associated KS. In 1994, Kaposi's sarcoma-associated herpesvirus (KSHV) or human herpesvirus type 8 was identified by Chang and colleagues, and has been detected worldwide at frequencies ranging from 80 to 100%. The aim of the present study was to evaluate the frequency of KSHV infection in KS lesions from HIV-positive and HIV-negative patients in Brazil, as well as to review the current knowledge about KS transmission and detection. For these purposes, DNA from 51 cases of KS was assessed by PCR: 20 (39.2%) cases of classical KS, 29 (56.9%) of AIDS-associated KS and 2 (3.9%) of iatrogenic KS. Most patients were males (7.5:1, M/F), and mean age was 47.9 years (SD = ± 18.7 years). As expected, HIV-positive KS patients were younger than patients with classical KS. On the other hand, patients with AIDS-associated KS have early lesions (patch and plaque) compared to classical KS patients (predominantly nodular lesions). This is assumed to be the result of the early diagnose of KS in the HIV-positive setting. KSHV infection was detected by PCR in almost all cases (48/51; 94.1%), irrespectively of the clinical-epidemiological form of KS. These results show that KSHV is associated with all forms of KS in Brazilian patients, a fact that supports the role of this virus in KS pathogenesis. (AU)

Processo FAPESP: 00/11130-2 - Interrelação do HHV-8 e apoptose em sarcoma da Kaposi e doença hematopoética
Beneficiário:Carlos Eduardo Bacchi
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 00/12248-7 - Inter-relação do HHV-8 e apoptose em sarcoma de Kaposi
Beneficiário:Suzane Ramos da Silva
Linha de fomento: Bolsas no Brasil - Iniciação Científica