Moderate exercise training promotes adaptations in coronary blood flow and adenosine production in normotensive rats

Autor(es)

Fernanda R. Roque ^[1] ; Ursula Paula Renó Soci ^[2] ; Katia De Angelis ^[3] ; Marcele A. Coelho ^[1] ; Cristina R. Furstenau ^[1] ; Dalton V. Vassallo ^[4] ; Maria Claudia Irigoyen ^[3] ; Edilamar M. Oliveira ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Sch Phys Educ & Sports, Biochem Lab, Sao Paulo - Brazil

^[2] University of São Paulo. School of Physical Education and Sports - Brasil

^[3] Univ Sao Paulo, Sch Med, Hypertens Unit, Inst Heart, Sao Paulo - Brazil

^[4] Univ Fed Espirito Santo, Sch Med, Dept Physiol Sci, Vitoria, ES - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Clinics; v. 66, n. 12, p. 2105-2111, 2011-00-00.

Resumo

OBJECTIVES: Aerobic exercise training prevents cardiovascular risks. Regular exercise promotes functional and structural adaptations that are associated with several cardiovascular benefits. The aim of this study is to investigate the effects of swimming training on coronary blood flow, adenosine production and cardiac capillaries in normotensive rats. METHODS: Wistar rats were randomly divided into two groups: control (C) and trained (T). An exercise protocol was performed for 10 weeks and 60 min/day with a tail overload of 5% bodyweight. Coronary blood flow was quantified with a color microsphere technique, and cardiac capillaries were quantified using light microscopy. Adenine nucleotide hydrolysis was evaluated by enzymatic activity, and protein expression was evaluated by western blot. The results are presented as the means ± SEMs (p<0.05). RESULTS: Exercise training increased the coronary blood flow and the myocardial capillary-to-fiber ratio. Moreover, the circulating and cardiac extracellular adenine nucleotide hydrolysis was higher in the trained rats than in the sedentary rats due to the increased activity and protein expression of enzymes, such as E-NTPDase and 59- nucleotidase. CONCLUSIONS: Swimming training increases coronary blood flow, number of cardiac capillaries, and adenine nucleotide hydrolysis. Increased adenosine production may be an important contributor to the enhanced coronary blood flow and angiogenesis that were observed in the exercise-trained rats; collectively, these results suggest improved myocardial perfusion. (AU)

• Processo FAPESP: 05/52100-2 - Efeitos do uso de esteroides anabolizantes associados ao treinamento fisico de natacao sobre o fluxo sanguineo para o miocardico de ratos normotensos.
• Beneficiário: Fernanda Roberta Roque Redondo
• Modalidade de apoio: Bolsas no Brasil - Mestrado