Silver Nanoparticles: Therapeutical Uses, Toxicity, and Safety Issues

Autor(es)

Dos Santos, Carolina Alves ^[1] ; Seckler, Marcelo Martins ^[1] ; Ingle, Avinash P. ^[2] ; Gupta, Indarchand ^{[2, 3]} ; Galdiero, Stefania ^{[4, 5]} ; Galdiero, Massimiliano ^[6] ; Gade, Aniket ^{[2, 7]} ; Rai, Mahendra ^[2]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Polytech Sch, Dept Chem Engn, BR-05508 Sao Paulo - Brazil

^[2] SGB Amravati Univ, Dept Biotechnol, Amravati 444602, Maharashtra - India

^[3] Inst Sci, Dept Biotechnol, Aurangabad 431004, Maharashtra - India

^[4] Univ Naples Federico II, CIRPEB, Dept Pharm, I-80314 Naples - Italy

^[5] CNR, Ist Biostrutture & Bioimmagini, I-80314 Naples - Italy

^[6] Univ Naples 2, Div Microbiol, Dept Expt Med, I-80138 Naples - Italy

^[7] Utah State Univ, Dept Biol, Logan, UT 84322 - USA

• Tipo de documento: Artigo de Revisão
• Fonte: Journal of Pharmaceutical Sciences; v. 103, n. 7, p. 1931-1944, JUL 2014.
• Citações Web of Science: 140

Resumo

The promises of nanotechnology have been realized to deliver the greatest scientific and technological advances in several areas. The biocidal activity of Metal nanoparticles in general and silver nanoparticles (AgNPs) depends on several morphological and physicochemical characteristics of the particles. Many of the interactions of the AgNPs with the human body are still poorly understood; consequently, the most desirable characteristics for the AgNPs are not yet well established. Therefore, the development of nanoparticles with well-controlled morphological and physicochemical features for application in human body is still an active area of interdisciplinary research. Effects of the development of technology of nanostructured compounds seem to be so large and comprehensive that probably it will impact on all fields of science and technology. However, mechanisms of safety control in application, utilization, responsiveness, and disposal accumulation still need to be further studied in-depth to ensure that the advances provided by nanotechnology are real and liable to provide solid and consistent progress. This review aims to discuss AgNPs applied in biomedicine and as promising field for insertion and development of new compounds related to medical and pharmacy technology. The review also addresses drug delivery, toxicity issues, and the safety rules concerning biomedical applications of silver nanoparticles. (c) 2014 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci 103:1931-1944, 2014 (AU)

• Processo FAPESP: 10/51933-9 - Sintese de nanoparticulas de prata com atividade antimicrobiana superior, promovida pela sua estabilizacao por copolimeros bioativos da classe dos pluronic
• Beneficiário: Carolina Alves dos Santos Pegoraro
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 12/03731-3 - Biossíntese de nanopartículas de prata por seleção de espécies de Phoma e suas atividades contra micróbios multirresistentes
• Beneficiário: Nelson Eduardo Duran Caballero
• Modalidade de apoio: Auxílio à Pesquisa - Pesquisador Visitante - Internacional